Skip to main content
SpringerLink
Log in

Sequence analysis of temperature sensitive and “neuraminidase-tolerant” mutants of Newcastle disease virus (strain Beaudette C)

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

Nucleotide sequence analysis of temperature sensitive and “neuraminidase-tolerant” mutants of Newcastle disease virus has identified sites in the haemagglutinin-neuraminidase protein which may be important in folding and function.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Alkhatib G, Briedis D (1986) The predicted primary structure of the measles virus hemagglutinin. Virology 150: 479–490

    Google Scholar 

  2. Blumberg B, Giorgi C, Roux L, Rajin R, Dowling P, Chollet A, Kolakofsky D (1985) Sequence determination of the Sendai virus HN gene and its comparison to the influenza virus glycoproteins. Cell 41: 269–278

    Google Scholar 

  3. Chambers P, Millar NS, Platt SG, Emmerson PT (1986) Nucleotide sequence of the gene encoding the matrix protein of Newcastle disease virus. Nucleic Acids Res 14: 9051–9061

    Google Scholar 

  4. Chambers P, Nesbit M, Yusoff K, Millar NS, Samson ACR, Emmerson PT (1988) Location of a neutralizing epitope for the haemagglutinin-neuraminidase glycoprotein of Newcastle disease virus. J Gen Virol 69: 2115–2122

    Google Scholar 

  5. Dahlberg JE (1968) Physical and genetic properties of Newcastle disease virus. PhD thesis, Purdue University, Lafayette, USA

    Google Scholar 

  6. Elango N, Coligan JE, Jambou RC, Venkatesan S (1986) Human parainfluenza type 3 virus hemagglutinin-neuraminidase glycoprotein: nucleotide sequence of mRNA and limited amino acid sequence of CNBr fragments of the purified protein. J Virol 57: 481–489

    Google Scholar 

  7. Harper DR, Samson ACR, Lee CM, Simon E (1983) A temperature-sensitive mutant of Newcastle disease virus which is affected in both haemagglutinin-neuraminidase and matrix proteins. J Gen Virol 64: 2781–2784

    Google Scholar 

  8. Hiebert SW, Paterson RG, Lamb RA (1985) Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: nucleotide sequence of the mRNA predicts an N-terminal membrane anchor. J Virol 54: 1–6

    Google Scholar 

  9. Jorgensen ED, Collins PL, Lomedico PT (1987) Cloning and nucleotide sequence of Newcastle disease virus hemagglutinin-neuraminidase mRNA: identification of a putative sialic acid binding site. Virology 156: 12–24

    Google Scholar 

  10. Kawano M, Bando H, Yuasa T, Kondo K, Tsurudome M, Komoda H, Nishio M, Ito Y (1990) Sequence determination of the hemagglutinin-neuraminidase (HN) gene of human parainfluenza type 2 virus and the construction of a phylogenetic tree for HN proteins of all the paramyxoviruses that are infectious to humans. Virology 174: 308–313

    Google Scholar 

  11. Matsuoka Y, Ray R, Compans W (1990) Sequence of the hemagglutinin-neuraminidase gene of parainfluenza virus type 1. Virus Res 16: 107–114

    Google Scholar 

  12. Millar NS, Chambers P, Emmerson PT (1986) Nucleotide sequence analysis of the haemagglutinin-neuraminidase gene of Newcastle disease virus. J Gen Virol 67: 1917–1927

    Google Scholar 

  13. Neyt C, Geliebter J, Slaoui M, Morales D, Meulemans G, Burny A (1989) Mutations located on both F1 and F2 subunits of the Newcastle disease virus protein confer resistance to neutralization with monoclonal antibodies. J Virol 63: 952–954

    Google Scholar 

  14. Precious B, Southern JA, Randall RE (1990) Sequence analysis of the HN gene of parainfluenza virus type 2. J Gen Virol 71: 1163–1168

    Google Scholar 

  15. Rima B (1989) Comparison of amino acid sequences of the major structural proteins of the paramyxo- and morbilliviruses. In: Kolakofsky D, Mahy BWJ (eds) Genetics and pathogenicity of negative strand viruses. Elsevier, Amsterdam, pp 254–263

    Google Scholar 

  16. Sakaguchi T, Toyoda T, Gotoh B, Inocencio NM, Kuma K, Miyata T, Nagai Y (1989) Newcastle disease virus evolution. I. Multiple lineages defined by sequence variability of the hemagglutinin-neuraminidase gene. Virology 169: 260–272

    Google Scholar 

  17. Samson ACR, Nesbit M, Lyon AM, Meulemans G (1988) Identification of haemagglutinin-neuraminidase antibody binding sites by Western blot analysis of antibody-resistant mutants and partial digest fragments of Newcastle disease virus. J Gen Virol 54: 1–6

    Google Scholar 

  18. Suzu S, Sakai Y, Shioda T, Shibuta H (1987) Nucleotide sequence of the bovine parainfluenza 3 virus genome: the genes of the F and HN glycoproteins. Nucleic Acids Res 15: 2945–2958

    Google Scholar 

  19. Tsukiyama K, Sugiyama M, Yoshikawa Y, Yamanouchi K (1987) Molecular cloning and sequence analysis of the rinderpest virus mRNA encoding the hemagglutinin protein. Virology 160: 48–54

    Google Scholar 

  20. Waxham NM, Aronowski J, Server AC, Wolinsky JS, Smith JA, Goodman HM (1988) Sequence determination of the mumps virus HN genome. Virology 164: 318–325

    Google Scholar 

  21. Yusoff K, Nesbit M, McCartney H, Emmerson PT, Samson ACR (1988) Mapping of three antigenic sites on the haemagglutinin-neuraminidase protein of Newcastle disease virus. Virus Res 11: 319–333

    Google Scholar 

  22. Yusoff K, Nesbit M, McCartney H, Meulemans G, Alexander DJ, Collins MS, Emmerson PT, Samson ACR (1989) Location of neutralizing epitopes on the fusion protein of Newcastle disease virus strain Beaudette C. J Gen Virol 70: 3105–3109

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Genetics, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, U.K.

    J. Hughes, K. Yusoff, R. Hardy, H. McCartney, P. T. Emmerson & A. C. R. Samson

Authors
  1. J. Hughes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Yusoff
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Hardy
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. McCartney
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. T. Emmerson
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. C. R. Samson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hughes, J., Yusoff, K., Hardy, R. et al. Sequence analysis of temperature sensitive and “neuraminidase-tolerant” mutants of Newcastle disease virus (strain Beaudette C). Archives of Virology 119, 141–146 (1991). https://doi.org/10.1007/BF01314330

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01314330

Keywords

Search

Navigation