Abstract
Human-Big-Gastrin I, a peptide hormone of 34 amino acid residues, and the 32-leucine analogue were synthesized. For this purpose six suitable peptide fragments were prepared at first, which subsequently were condensed to the total sequence. In this paper we describe the syntheses of four suitably protected peptide fragments corresponding to the sequences 28–34, 23–27, 21–22 and 15–20 of human-big-gastrin I. For the protection of the side-chain functionstert-butanol derived groups removable in the final step by acidolytic cleavage were used. The α-amino-functions were selectively blocked as benzyloxycarbonyl-and 2-nitrophenylsulfenyl-derivatives, respectively.
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Abkürzungen: Es werden hier vorwiegend die von der IUPAC-IUB Commission on Biochemical Nomenclature empfohlenen Abkürzungen für Aminosäuren und Schutzgruppen verwendet. Wegen der universellen Anwendbarkeit bedienen sich die Autoren auch der imHouben-Weyl 2 niedergelegten und eingehend erläuterten Abkürzungen.DCCD=N,N′-Dicyclohexylcarbodiimid,HONSu=N-Hydroxysuccinimid.
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Wendlberger, G., Moroder, L., Hallett, A. et al. Zur Synthese von Human-Big-Gastrin I und seinem 32-Leucin-Analogon 1. Mitteilung: Darstellung der Teilsequenzen 28–34, 23–27, 21–22 und 15–20. Monatshefte für Chemie 110, 1301–1315 (1979). https://doi.org/10.1007/BF00938288
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DOI: https://doi.org/10.1007/BF00938288