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Synthesis and Haemolytic Activity of Oleanolic Acid Trisaccharides

Synthese und hämolytische Wirkung von Oleanolsäuretrisacchariden

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Summary.

 The first partial synthesis of monodesmosidic oleanolic acid trisaccharides is described. Their haemolytic index is lower compared to the corresponding disaccharide. The influence of the linkage and the configurations of the carbohydrate units on the haemolytic activity of these saponins was investigated.

Zusammenfassung.

 Es wird die erste Partialsynthese monodesmosidischer Oleanolsäuretrisaccharide beschrieden. Ihr hämolytischer Index ist niedriger als der des entsprechenden Disaccharids. Untersucht wurde der Einfluß der Verknüpfung sowie der Konfiguration der Kohlehydrateinheiten auf die hämolytische Aktivität dieser Saponine.

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Authors and Affiliations

  1.  Institute of Pharmaceutical Chemistry, University of Graz, Austria, AT

    Werner Seebacher, Robert Weis & Ernst Haslinger

  2.  Institute of Pharmacognosy, University of Vienna, Austria, AT

    Johann Jurenitsch & Katharina Rauchensteiner

Authors
  1. Werner Seebacher
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  2. Robert Weis
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  3. Johann Jurenitsch
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  4. Katharina Rauchensteiner
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  5. Ernst Haslinger
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Additional information

Received March 25, 1999. Accepted April 19, 1999

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Seebacher, W., Weis, R., Jurenitsch, J. et al. Synthesis and Haemolytic Activity of Oleanolic Acid Trisaccharides. Monatshefte fuer Chemie 130, 1383–1391 (1999). https://doi.org/10.1007/PL00010198

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  • DOI: https://doi.org/10.1007/PL00010198

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