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Synthesis and Hemolytic Propertiesof Arvensoside B Isomers

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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Summary.

 The first partial syntheses of galactosyl-glucosyl oleanolic acid disaccharides are described. Arvensoside B and calenduloside A, which have earlier been isolated from Calendula arvensis and Calendula officinalis, and some further oleanolic acid glycosides were prepared from differently linked acetobromo sugars. The hemolytic properties of these saponins were investigated. Systematic variation of the carbohydrate structure and comparison with already synthesized glucosyl-glucosyl analogues enable general conclusions about structure-activity relationships.

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Authors and Affiliations

  1.  Institute of Pharmaceutical Chemistry, University of Graz, Austria, , , , , , AT

    Werner Seebacher, Robert Weis & Ernst Haslinger

  2.  Institute of Pharmacognosy, University of Vienna, Austria, , , , , , AT

    Johann Jurenitsch & Katharina Rauchensteiner

Authors
  1. Werner Seebacher
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  2. Robert Weis
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  3. Johann Jurenitsch
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  4. Katharina Rauchensteiner
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  5. Ernst Haslinger
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Additional information

Received April 17, 2000. Accepted May 3, 2000

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Seebacher, W., Weis, R., Jurenitsch, J. et al. Synthesis and Hemolytic Propertiesof Arvensoside B Isomers. Monatshefte für Chemie 131, 985–996 (2000). https://doi.org/10.1007/s007060070055

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  • DOI: https://doi.org/10.1007/s007060070055

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