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d-Aminoaciduria in mutant mice lackingd-amino-acid oxidase activity

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Summary

Urine of mutant ddY/DAO− mice lackingd-amino-acid oxidase activity contained more serine and proline than that of normal ddY/DAO+ mice.d-Amino-acid oxidase treatment of urinary amino acids decreased the serine and proline, suggesting that they containedd-isomers. An HPLC analysis confirmed the presence ofd-serine. Urinary serine and proline contents were not decreased when the ddY/DAO− mice were fed a diet which did not contain supplementaryd-methionine or when they were given water containing antibiotics. These results suggest that thed-serine andd-proline do not derive from thed-methionine supplemented in the diet or from intestinal bacteria. In urine of the ddY/DAO− mice, a substance which seemed to bed-methionine sulfoxide and/ord-methionine sulfone was present. It is probably a metabolite of thed-methionine supplemented in the diet. Thed-aminoaciduria in the mutant mice lackingd-amino-acid oxidase activity indicates that this enzyme is involved in the metabolism of thed-amino acids in normal mice.

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Authors and Affiliations

  1. Department of Microbiology, Dokkyo University School of Medicine, 321-02, Mibu, Tochigi, Japan

    R. Konno, A. Niwa & Y. Yasumura

  2. Department of Laboratory of Medical Sciences, Dokkyo University School of Medicine, 321-02, Mibu, Tochigi, Japan

    M. Ikeda

Authors
  1. R. Konno
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  2. M. Ikeda
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  3. A. Niwa
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  4. Y. Yasumura
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Konno, R., Ikeda, M., Niwa, A. et al. d-Aminoaciduria in mutant mice lackingd-amino-acid oxidase activity. Amino Acids 1, 239–246 (1991). https://doi.org/10.1007/BF00806921

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