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Deficiencies of essential fatty acids and vitamin E in cystic fibrosis

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Summary

In 25 children (13 male; 12 female) with cystic fibrosis aged 6 months to 16 years and 24 matched controls total serum vitamin E levels and fatty acid patterns of serum cholesterol esters, phospholipids and triglycerides are demonstrated.

Compared to controls (1.02±0.24 mg/dl) the total serum vitamin E levels are significantly decreased in patients with cystic fibrosis (0.30±0.26 mg/dl) (p<0.01). There is no significant difference comparing the fatty acid patterns of the serum ester fractions of both groups. Differences can be seen best in the cholesterol ester fraction. In this fraction linoleic acid shows a trend to be decreased in the cystic fibrosis patients compared to the control group.

A possible influence of height velocity on the levels of essential fatty acids is discussed.

Zusammenfassung

Bei 25 Patienten mit Mukoviszidose (13 männlich, 12 weiblich) und entsprechenden Kontrollen wurden der Serum-Vitamin-E-Spiegel und das Fettsäuremuster von Serumcholesterinestern, Serumphospholipiden und Serumtriglyzeriden untersucht. Im Vergleich zu Kontrollpatienten (1,02±0,24 mg/100 ml) war der Serum-Vitamin-E-Spiegel bei den Patienten mit Mukoviszidose signifikant erniedrigt (0,30±0,26 mg/100 ml) (p<0,01). Zwischen beiden Gruppen besteht kein signifikanter Unterschied des Fettsäuremusters. Unterschiede sind jedoch aus der-Serumcholesterinesterfraktion am besten ersichtlich. Hier ist die Linolsäurekonzentration im Mittelwert bei den Patienten mit Mukoviszidose im Vergleich zu den Kontrollen erniedrigt.

Ein möglicher Einfluß der Wachstumsgeschwindigkeit wird diskutiert.

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Author notes

  1. H. Böhles

    Present address: Universitätskinderklinik Erlangen, Deutschland

Authors and Affiliations

  1. Universitätskinderklinik Erlangen, Deutschland

    H. Heid, K. Stehr & W. Fekl

  2. Institut für experimentelle Ernährung e.V., Erlangen

    H. Böhles, H. Heid, K. Stehr & W. Fekl

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  1. H. Böhles
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  3. K. Stehr
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Böhles, H., Heid, H., Stehr, K. et al. Deficiencies of essential fatty acids and vitamin E in cystic fibrosis. Z Ernährungswiss 18, 81–87 (1979). https://doi.org/10.1007/BF02023721

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