Skip to main content
SpringerLink
Log in

Effects of nitroglycerin and dipyridamole on regional myocardial blood flow

Einfluß von Nitroglycerin und Dipyridamol auf die regionale Blutströmung im Myokard

  • Original Contributions
  • Published:
Basic Research in Cardiology Aims and scope Submit manuscript

Summary

The effects of intravenous administration of nitroglycerin or dipyridamole on distribution of myocardial blood flow in the heart after coronary underperfusion were investigated. In 18 open chest, anesthetized dogs, flow of the tubing supplying the left circumflex coronary artery (LCA) was reduced and kept constant, and then the drug was given intravenously. Before and after an administration of saline, nitroglycerin (0.04 mg/kg) and dipyridamole (0.2 mg/kg), myocardial blood flow was measured by tracer microspheres (TM). The first and second carbonized 15 μ spheres (TM1 and TM2) were injected into the left atrium and the cannulated LCA perfusion system respectively before medication. Similarly, the third and fourth spheres were given after drug. Thus, by using four different TMs (141Ce,51Cr,85Sr,46Sc) regional myocardial blood flow from the LCA perfusion route (TM2 and TM4) was measured separately from that of the other normally perfused coronary route (TM1 and TM3). The effect of drugs on flow distribution of these two independent routes was measured.

The LCA underperfusion produced a significant diminution of regional flow and its end/epi ratio in the LCA territory. Nitroglycerin increased end/epi ratio in the ischemic myocardium in the LCA perfusion route, but dipyridamole increased the normally perfused coronary flow but caused a shift of flow from the ischemic left ventricle to the atria and right ventricle within the LCA territory.

Zusammenfassung

Die Auswirkungen einer intravenösen Verabfolgung von Nitroglycerin und Dipyridamol auf die Verteilung der Blutströmung im Herzen nach koronarer Mangelperfusion wurde untersucht. Bei 18 narkotisierten Hunden mit eröffnetem Thorax wurde der Zufluß zum Ram. circumflexus der linken Koronararterie (LCA) reduziert und konstant gehalten. Dann wurde die Substanz intravenös injiziert. Vor und nach Verabfolgung von Kochsalz, Nitroglycerin (0,04 mg/kg) und Dipyridamol (0,2 mg/kg) wurde die myokardiale Stromstärke nach der Microsphere-Methode gemessen. Die erste und zweite Dosis der Kügelchen (TM1 und TM2) wurde vor der Medikation in den linken Vorhof bzw. in das Perfusionssystem des kanulierten Ram. circumflexus injiziert. In ähnlicher Weise wurde eine dritte und vierte Dosis von Microspheres nach der Medikation verabfolgt. So wurde durch vier verschiedene Gaben von Microspheres (141Ce,51Cr,85Sr,46Sc) die regionale Blutströmung, ausgehend vom Perfusionssystem des Ram. circumflexus (TM2 und TM4) getrennt gemessen von dem übrigen, normalperfundierten Koronarsystem (TM1 und TM3). Der Einfluß der Substanzen auf die Verteilung der Blutströmung in diesen beiden unabhängigen Bereichen wurde gemessen. Die Mangelperfusion des Ram. circumflexus bewirkte eine eindeutige Verminderung der regionalen Blutströmung und des Verhältnisses von endokardialer zu epikardialer Region im Versorgungsbereich des Ram. circumflexus.

Nitroglycerin erhöhte im Perfusionsbereich des Ram. circumflexus dieses Verhältnis innerhalb des ischämischen Myokards. Dipyridamol dagegen erhöhte die Stromstärke im übrigen Koronarsystem, verursachte aber eine Verlagerung der Stromstärke vom ischämischen Bereich zu den Vorhöfen und zum rechten Ventrikel im Versorgungsbereich des Ram. circumflexus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bunn, W. H., Jr., A. N. Chremos: Clinical evaluation of sublingual nitrates: Onset and duration of action of nitroglycerin and isosorbide dinitrate. Angiology14, 48–54 (1963).

    PubMed  Google Scholar 

  2. Kinsella, D., W. Troup, M. McGregor: Studies with a new coronary vasodilator drug: Persantin. Am. Heart J.63, 146–151 (1962).

    PubMed  Google Scholar 

  3. Wendt, V. E., J. F. Sundermeyer, P. B. den Bakker, R. J. Bing: The relationship between coronary blood flow, myocardial oxygen consumption and cardiac work as influenced by persantin. Am. J. Cardiol.9, 449–454 (1962).

    PubMed  Google Scholar 

  4. Eliott, E. C., D. Secord, C. Heath: The effects of dipyridamole and nitroglycerin on coronary blood flow, mean arterial pressure, and heart rate in dogs. Can. J. Physiol. Pharmacol.43, 663–673 (1965).

    PubMed  Google Scholar 

  5. Nakamura, M., Y. Etoh, N. Hamanaka, A. Kuroiwa, H. Tomoike, Y. Ishihara: Effects of selective coronary hypotension and nitroglycerin or Bay a 1040 on the distribution of Rb86 clearance in the canine heart. Cardiovasc. Res.7, 777–788 (1973).

    PubMed  Google Scholar 

  6. Bache, R. J., R. M. Ball, F. R. Cobb, J. C. Rembert, J. C. Greenfield Jr: Effects of nitroglycerin on transmural myocardial blood flow in the unanesthetized dog. J. Clin. Inv.55, 1219–1228 (1975).

    Google Scholar 

  7. Mathes, P., J. Rival: Effect of nitroglycerin on total and regional coronary blood flow in the normal and ischaemic canine myocardium. Cardiovasc. Res.5, 54–61 (1971).

    PubMed  Google Scholar 

  8. Rees, J. R., V. J. Redding: Effects of dipyridamole on anastomotic blood flow in experimental myocardial infarction. Cardiovasc. Res.1, 179–183 (1967).

    PubMed  Google Scholar 

  9. Linder, E., T. Seeman: Effects of persantin and nitroglycerin on myocardial blood flow during temporary coronary occlusion in dogs. Angiologica4, 225–255 (1967).

    PubMed  Google Scholar 

  10. Pasyk, S., C. M. Bloor, E. M. Khouri, D. E. Gregg: Systemic and coronary effects of coronary artery occlusion in the unanesthetized dog. Am. J. Physiol.220, 646–654 (1971).

    PubMed  Google Scholar 

  11. Schaper, W.: The collateral circulation of the heart. Amsterdam: North Holland 1971).

    Google Scholar 

  12. Fam, W. M., M. McGregor: Effect of nitroglycerin and dipyridamole on regional coronary resistance. Circ. Res.22, 649–659 (1968).

    PubMed  Google Scholar 

  13. Domenech, R. J., J. I. E. Hoffman, M. I. M. Noble, K. B. Saunders, J. R. Henson, S. Subijanto: Total and regional coronary blood flow measured by radioactive microspheres in conscious and anesthetized dogs. Circ. Res.25, 581–596 (1969).

    PubMed  Google Scholar 

  14. Dorner, J., E. Wick: Comparative investigations of the efficacy of commonly used coronary vasodilator drugs in anesthetized and unanesthetized dogs. Arzneim.-Forschg.10, 631–639 (1960).

    Google Scholar 

  15. Warltier, D. C., H. F. Hardman, A. R. Laddue, P. Somani, G. J. Gross: Myocardial distribution of coronary blood flow in the isolated supported heart preparation. Cardiovasc. Res.9, 634–639 (1975).

    PubMed  Google Scholar 

  16. Buckberg, G. D., J. C. Luck, B. D. Payne, T. I. E. Hoffman, T. P. Archie, E. D. Fixler: Some sources of error in measuring regional blood flow with radioactive microspheres. J. Appl. Physiol.31, 598–604 (1971).

    PubMed  Google Scholar 

  17. Tomoike, H., Y. Nose, O. Nakagaki, T. Fukuyama, A. Kuroiwa, M. Nakamura: A study of the effects of propranolol and/or Kö 1366 on the distribution of Rb86 clearance in the canine heart under selective coronary hypotension. Arzneim.-Forschg. (Drug Res.)25, 765–769 (1975).

    Google Scholar 

  18. Bui-Mong-Hung, R. M. Desmottes, M. DeMendonca, M. Appel, C. Dangles, J. Hinglais: Biochemical heterogenity of the left ventricular myocardium: transmural and base-apex gradients on H.E.P. contents of the well oxygenated perfused dog heart. Arch. Intern. Physiol. Biochem.84, 269–276 (1976).

    Google Scholar 

  19. Watanabe, T., F. Shintani, L. Fu, K. Kato, S. Koyama: Failure of dipyridamole (persantin) in reducing the infarct size following experimental coronary occlusion. Jap. Heart J.13, 512–520 (1972).

    PubMed  Google Scholar 

  20. Becker, L. C.: Effect of nitroglycerin and dipyridamole on regional left ventricular blood flow during coronary occlusion. J. Clin. Invest58, 1287–1296 (1976).

    PubMed  Google Scholar 

  21. Szekeres, L., V. Csik, E. Udvary: Nitroglycerin and dipyridamole on cardiac metabolism and dynamics in a new experimental model of angina pectoris. J. Pharmacol Exp. Therap.196, 15–28 (1976).

    Google Scholar 

  22. Mosher, P., J. Ross, P. A. McFate, R. F. Shaw: Control of coronary blood flow by an autoregulatory mechanism. Circ. Res.14, 250–259 (1964).

    PubMed  Google Scholar 

  23. Khouri, E. M., D. E. Gregg, H. S. Lowensohn: Flow in the major branches of the left coronary artery during experimental coronary insufficiency in the unanesthetized dog. Circ. Res.23, 99–109 (1968).

    PubMed  Google Scholar 

  24. Malindzak, G. S., H. D. Green, P. L. Stagg: Effects of nitroglycerin on flow after partial constriction of the coronary artery. J. Appl. Physiol.29, 17–22 (1970).

    PubMed  Google Scholar 

  25. Gould, K. L., K. Lipscomb, C. Calvert: Compensatory changes of the distal coronary vascular bed during progressive coronary constriction. Circ.51, 1085–1094 (1975).

    Google Scholar 

Download references

Author information

Author notes

  1. M. Nakamura

    Present address: Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University Medical School, 3-1-1 Maidashi, Fukuoka, Japan

Authors and Affiliations

  1. Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University Medical School, 3-1-1 Maidashi, Fukuoka, Japan

    O. Nakagaki, Y. Nose, T. Fukuyama & Y. Kikuchi

Authors
  1. M. Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. Nakagaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. Nose
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Fukuyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Y. Kikuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

With 2 figures and 5 tables

This study was financed by grants from the Japanese Ministry of Education (No. 144051) and Mitsui Life Social Welfare Foundation.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nakamura, M., Nakagaki, O., Nose, Y. et al. Effects of nitroglycerin and dipyridamole on regional myocardial blood flow. Basic Res Cardiol 73, 482–496 (1978). https://doi.org/10.1007/BF01906528

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01906528

Keywords

Search

Navigation