Summary
Effects of alpha adrenergic stimulation on diameter change of the epicardial coronary artery were studied in in-situ canine heart. The diameter of the left circumflex coronary artery (LCX) was continuously measured by 10 MHz PZT crystals applied to the external wall of the LCX. Aortic pressure was measured using high fidelity catheter-tip manometer.
Enhanced activity of alpha adrenergic receptor by humoral and/or somatic nerve stimulations caused a reduction of the LCX diameter despite of the systemic pressure rise.
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This project was supported in parts by Grant-in-Aid for Special Project Research (No. 412009 and 422023) from the Ministry of Education, Science and Culture, Japan.
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Nakamura, M., Tomoike, H., Ootsubo, H. et al. Constriction of the epicardial coronary artery induced by α-adrenergic stimulation. Basic Res Cardiol 76, 498–502 (1981). https://doi.org/10.1007/BF01908350
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DOI: https://doi.org/10.1007/BF01908350