Summary
17 animals out of a group of 25 Sprague-Dawley rats, injected subcutaneously with 120 mg/kg n-butyl-nitrosourea on their first day of life, developed 29 neurogenic malignancies. The medium induction time of the tumors was about 290 days. Tumors were never seen at site of injection. 5 animals still alive will be observed until their natural death.
The single application of n-butyl-nitrosourea (BNU) to newborn rats is considered to give a simple and appropriate model for the induction of neurogenic tumors in neuro-oncological studies.
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Zeller, W.J., Ivankovic, S. Cancerogene Wirkung einer einmaligen subcutanen Gabe von n-Butyl-nitrosoharnstoff an neugeborenen Ratten. Z. Neurol. 202, 121–127 (1972). https://doi.org/10.1007/BF00316161
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DOI: https://doi.org/10.1007/BF00316161