Summary
The cellular distribution of parvalbumin-like immunoreactivity (PA-LI) in the human brain was investigated by peroxidase-antiperoxidase methods using antiserum to rat skeletal muscle parvalbumin. PA-LI was present in non-pyramidal neurons of the cerebral cortices, stellate cells, basket cells and Purkinje cells in cerebellar cortices, and neurons of some nuclei in human brain stem; the distribution of PA-LI in human brain was very similar to that in rat brain. These results indicate that PA-LI is widely distributed in a specific subpopulation of neurons of the human brain.
Similar content being viewed by others
References
Alonso JR, Coveñas R, Lara J, Aijón J (1990) Distribution of parvalbumin immunoreactivity in the rat septal area. Brain Res Bull 24:41–48
Berchtold MW, Celio MR, Heizmann CW (1985) Parvalbumin in human brain. J Neurochem 45:235–239
Celio MR, Heizmann CW (1981) Calcium-binding protein parvalbumin as a neuronal marker. Nature 293:300–302
Endo T, Onaya T (1988) Immunohistochemical localization of parvalbumin in rat and monkey autonomic ganglia. J Neurocytol 7:73–77
Endo T, Kobayashi S, Onaya T (1985) Parvalbumin in rat cerebrum, cerebellum and retina during postnatal development. Neurosci Lett 60:279–282
Endo T, Kobayashi M, Kobayashi S, Onaya T (1986) Immunocytochemical and biochemical localization of parvalbumin in the retina. Cell Tissue Res 243:213–217
Endo T, Takazawa K, Kobayashi S, Onaya T (1986) Immunochemical and immunohistochemical localization of parvalbumin in rat nervous tissues. J Neurochem 46:892–898
Gerfen CR, Baimbridge KG, Miller JJ (1985) The neostriatal mosaic: compartmental distribution of calcium-binding protein and parvalbumin in the basal ganglia of the rat and monkey. Proc Natl Acad Sci USA 82:8780–8784
Gillis JM, Thomason D, Lefevre J, Kretsinger RJ (1982) Parvalbumin and muscle relaxation; computer stimulation study. Muscle Res Cell Motil 3:377–398
Haiech J, Derancourt J, Pechere JF, Demaille JG (1979) Magnesium and calcium binding to parvalbumin; evidence for difference between parvalbumin and an explanation of their relaxing function. Biochemistry 13:2752–2758
Heizmann CW (1984) Parvalbumin, an intracellular calciumbinding protein, distribution, properties and possible role in mammalian cells. Experientia (Basel) 40:910–921
Heizmann CW, Berchtold MW, Rowlerson AM (1982) Correlation of parvalbumin concentration with relaxing speed in mammalian muscles. Proc Natl Acad Sci USA 79:7243–7247
Muntener M, Berchthold MW, Heizmann CW (1985) Parvalbumin in cross-reinnervated and denervated muscles. Muscle Nerve 8:132–137
Pechere JF, Derancourt J, Haiech J (1979) The participation of parvalbumin in the activation-relaxation cycle of vertebrate fast skeletal muscle. FEBS Lett 75:111–114
Sternberger LA (1979) Immunohistochemistry, 2nd edn. Wiley, New York, pp 58–81
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ohshima, T., Endo, T. & Onaya, T. Distribution of parvalbumin immunoreactivity in the human brain. J Neurol 238, 320–322 (1991). https://doi.org/10.1007/BF00315329
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00315329