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Modulatory effects of calcitonin gene-related peptide and substance P on human cholinergic sweat secretion

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Abstract

Immunoreacttvtty to various peptides has been demonstrated in nerve terminals around the sweat glands, suggesting a regulatory function for these peptides on sweating. The present study evaluated the calcitonin-gene related peptide and substance P related regulation of sweating in man. Both calcitonin-gene related peptide and substance P, when administered alone, failed to cause sweat secretion, whereas sweating induced by methacholine chloride alone was four times greater when administered with calcitonin-gene related peptide and suppressed by 70% when administered with substance P. The degree of calcitonin-gene related peptide dependent augmentation and substance P dependent suppression of the methacholine chloride induced sweating was dependent on the concentration of calcitonin-gene related peptide and substance P. These findings suggest that calcitonin-gene related peptide enhances cholinergic sweating and substance P inhibits it.

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Authors and Affiliations

  1. Department of Internal Medicine and Department of Physiology, Aichi Medical University, 480-11, Nagakute, Aichi, Japan

    Kazuhiko Kumazawa MD, Gen Sobue MD, Terunori Mitsuma MD & Tokuo Ogawa MD

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  1. Kazuhiko Kumazawa MD
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  2. Gen Sobue MD
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  3. Terunori Mitsuma MD
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  4. Tokuo Ogawa MD
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Kumazawa, K., Sobue, G., Mitsuma, T. et al. Modulatory effects of calcitonin gene-related peptide and substance P on human cholinergic sweat secretion. Clinical Autonomic Research 4, 319–322 (1994). https://doi.org/10.1007/BF01821532

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  • DOI: https://doi.org/10.1007/BF01821532

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