Summary
A group of 17 β-carbolines was studied in HPLC and TLC systems in order to predict their partition coefficients (log P values). On account of the basic or acid character of some of these compounds, an ion pairing system gave the best results. Both HPLC and TLC data were comparable for log P prediction but severe pH conditions required the use of TLC plates. Retention data are quantitatively related to lipophilicity (expressed as the Hansch constant) and polarity (as the inductive constant) of the solute molecule.
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Pietrogrande, M.C., Borea, P.A., Lodi, G. et al. Reversed-phase ion-pair systems to predict partition coefficients of β-carbolines by HPLC and TLC. Chromatographia 23, 713–716 (1987). https://doi.org/10.1007/BF02312661
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DOI: https://doi.org/10.1007/BF02312661