Summary
A headspace gas chromatographic method for determination of traces of ethylene oxide (EO) in sterilized materials has been developed. The method allows the determination of the amount of EO by putting the samples directly into acetonitrile and analysing by means of headspace GC.
The procedure described is simple, sensitive, reproducible and linear. The lower limit of detection is 0.015 μg/g of sterilized material.
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References
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M. V. Russo, G. Goretti, A. Liberti, J. HRC & CC,8, 535 (1985).
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Russo, M.V. Headspace gas chromatographic analysis for the determination of traces of ethylene oxide in sterilized materials. Chromatographia 27, 469–471 (1989). https://doi.org/10.1007/BF02319567
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DOI: https://doi.org/10.1007/BF02319567