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Feasible solutions for optimization problems involving unresolved peaks using retention prediction and information theory

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Summary

This paper treats optimization problems involving unresolved component peaks with the information measure FUMI (Function ofMutualInformation) as a criterion. The LC analysis of 20 PTH-amino acids is taken as an example of the optimization of mobile phase composition, column length and temperature. The quantitative structure-retention relationship is adopted for the simulation and for the establishment of feasible solutions of the problems. The applicability of the FUMI theory is further extended by solving the above optimization problems.

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Authors and Affiliations

  1. National Institute of Hygienic Sciences, 1-18-1, Kamiyoga, Setagaya, 158, Tokyo, Japan

    Y. Hayashi & R. Matsuda

  2. School of Materials Science, Toyohashi University of Technology, 44, Toyohashi, Japan

    K. Jinno

Authors
  1. Y. Hayashi
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  2. R. Matsuda
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  3. K. Jinno
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Hayashi, Y., Matsuda, R. & Jinno, K. Feasible solutions for optimization problems involving unresolved peaks using retention prediction and information theory. Chromatographia 31, 554–560 (1991). https://doi.org/10.1007/BF02279475

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  • DOI: https://doi.org/10.1007/BF02279475

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