Summary
Porous, perfluoroalkylated polymer-gels for column packings in high-performance liquid chromatography (HPLC) were prepared by suspension polymerization of heptadecafluorodecyl arcylate and ethylene glycol dimethacrylate. The packings showed no abnormal retention for ionic or aromatic compounds, due to the lack of ionic or aromatic groups. In addition, the packings showed no excessive retention for strongly hydrophobic compounds which is often the case with long-chain, alkylated silica gels and polymer gels. This is due to the extremely low surface energy of perfluoroalkyl groups. Therefore, perfluoroalkylated polymer gels enable isocratic HPLC separation of solutes with significantly different hydrophobicity.
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Hirayama, C., Ihara, H., Nagaoka, S. et al. Isocratic HPLC separation of aromatic hydrocarbons and fluorine-containing compounds using perfluoroalkyl polymer packings. Chromatographia 33, 473–477 (1992). https://doi.org/10.1007/BF02262330
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DOI: https://doi.org/10.1007/BF02262330