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T-Cell Recognition of Proteins: Conclusions From the Localization of the Full T-Cell Recognition Profiles of Two Native Proteins

Bio/Technology volume 3, pages 47–54 (1985)Cite this article

Abstract

Previous studies from this laboratory were the first to define all the sites recognized by antibodies (i.e. antigenic sites) in several protein antigens. Recently, using a comprehensive synthetic strategy, we have scanned the entire polypeptide chains of myoglobin and lysozyme and have determined the full profile of the continuous sites of T-cell recognition for each protein. Together, these studies have enabled the first detailed comparison, at the sub-molecular level, of the protein regions involved in T- and B-cell recognition.

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Authors and Affiliations

  1. Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX, 77030

    Garvin S. Bixler Jr. & M. Zouhair Atassi

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  1. Garvin S. Bixler Jr.
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  2. M. Zouhair Atassi
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Bixler, G., Atassi, M. T-Cell Recognition of Proteins: Conclusions From the Localization of the Full T-Cell Recognition Profiles of Two Native Proteins. Nat Biotechnol 3, 47–54 (1985). https://doi.org/10.1038/nbt0185-47

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