Abstract
WHEN the nonapeptide bradykinin is injected into tissue certain effects follow1. These are: stimulation of smooth muscle, vasodilation with increased capillary permeability, and the production of pain. With large doses there is also attraction of masses of leucocytes to the injected site. No specific antagonist of bradykinin has yet been discovered and Lewis1 regards the material as a local tissue hormone capable of producing a typical early inflammatory response.
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References
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ARCHER, R., BROOME, J. Bradykinin and Eosinophils. Nature 198, 893–894 (1963). https://doi.org/10.1038/198893a0
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DOI: https://doi.org/10.1038/198893a0
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