Induction of Resistance to an Isologous Tumour by Ultra-violet Attenuated Tumour Cells

Abstract

IN a previous publication from these laboratories it was demonstrated that the intravenous injection of a viable cell suspension of tumour, the dbrB adenocarcinoma, indigenous to the strain of origin, the DBA/1 mouse, elicited complete resistance to the growth of a subsequent subcutaneous implant of this same tumour, but that many of the animals died of pulmonary tumours resulting from the primary intravenous injection of viable tumour cells¹. Further, when this same strain of animal was pretreated intravenously with similar tumour cells attenuated or killed with alcohol, in an effort to eliminate the development of lung tumours, only partial resistance to challenge growth was effected².