Abstract
IN a series of histochemical studies on tissues of the human and of rats and mice, the activity of the enzyme 6-phosphogluconate dehydrogenase was found to be remarkably increased in proliferating cells, whether they were benign or malignant. This enzyme is part of the respiratory mechanism known as the pentose pathway, or ‘shunt’, which may provide an alternative glycolytic pathway from glucose to pyruvate; it may also be implicated in the synthesis of the nucleic acids1. Because of the possible significance of the results obtained in diverse experiments during the past two years, it was considered advisable to communicate these preliminary findings.
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References
Glock, G. E., in The Nucleic Acids, 2, 247 (Academic Press, New York, 1955); in The Biochemists' Handbook, edit. by Long, C., 345 (Spon, London, 1961).
Cunningham, G. J., Bitensky, L., Chayen, J., and Silcox, A. A., Acta Histochem. (in the press).
Gahan, P. B. (personal communication).
Glock, G. E., and McLean, P., Biochem. J., 55, 400 (1953).
Elson, L. A., Brit. J. Cancer, 6, 392 (1952).
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CHAYEN, J., BITENSKY, L., AVES, E. et al. Histochemical Demonstration of 6-Phosphogluconate Dehydrogenase in Proliferating and Malignant Cells. Nature 195, 714–715 (1962). https://doi.org/10.1038/195714b0
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DOI: https://doi.org/10.1038/195714b0
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