Abstract
THE properties of Sandoz ‘M.S. 222’ compound, a meta-amino-benzoic acid ethyl ester in the form of a soluble salt, as a general anæsthetic1,2 have led to its widespread use in studies of fish physiology. The general effects of this, and other anæsthetics on fish, have been examined by McFarland3, but, in the course of experiments on some aspects of the respiratory and circulatory physiology of teleosts, it became clear that ‘M.S. 222’ caused changes of considerable significance not hitherto described.
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References
Gilbert, P. W., and Wood, F. G., Science, 126, 212 (1957).
Ball, J. N., and Cowan, P. N., Nature, 184, 370 (1959).
McFarland, W. N., Pub. Inst. Mar. Sci. Univ. Tex, 6, 23 (1959).
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RANDALL, D. Effect of an Anæsthetic on the Heart and Respiration of Teleost Fish. Nature 195, 506 (1962). https://doi.org/10.1038/195506a0
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DOI: https://doi.org/10.1038/195506a0
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