Abstract
THE exchange or renewal reactions of deoxyribonucleic acid (DNA) in non-dividing cells have been proved by many investigators1. But the DNA does not seem to be in a dynamic state in erythrocytes of birds2. Indeed, Allfrey and Mirsky did not find incorporation of nitrogen-15 from 15N-glycine into DNA of chicken red cells in vitro. On the contrary, studying the fixation of carbon-14 from NaH14CO3 by duck red cells in vitro we found that DNA was radioactive3. Both carbon dioxide and glycine are precursors of DNA1.
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References
Broda, E., Radioactive Isotopes in Biochemistry, 255 (Elsevier Pub. Co., London, 1960).
Allfrey, V., and Mirsky, A. E., J. Gen. Physiol., 35, 841 (1952).
Giustina, G., and Lazzarini, E., Nature, 182, 1311 (1958).
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Sutherland, G. B. B. M., First Lomb. Sci. e Lett. Convergno Antonio Baselli “Le macromole dei viventi” (1955).
Barton, K., Biochem. J., 62, 315 (1956).
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BIANCO, L., GIUSTINA, G. & LAZZARINI, E. Incorporation in vitro of Carbon-14 from NaH14CO3 and 214C-Glycine into DNA of Red Cells of the Duck. Nature 194, 289–290 (1962). https://doi.org/10.1038/194289a0
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DOI: https://doi.org/10.1038/194289a0
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