Abstract
IN skin carcinogenesis induced in the mouse by chemical means a striking accumulation of mast cells has been observed in the altered dermis during the ‘precancerous’ stages of tumour formation1,2. Unlike the mast cells of normal mouse skin these accumulating mast cells have been reported to exhibit a strong primary golden-yellow fluorescence when the specimens are examined in ultra-violet light, after formol fixation. Since normal3 as well as tumorous4,5 mast cells of mouse are known to contain significant stores of 5-hydroxytryptamine (5-HT), together with histamine and heparin, it has been suggested that the fluorescence acquired by dermal mast cells in skin carcinogenesis was due to a remarkable increase of the 5-HT cellular content2,6. However, a number of questions regarding the morphology and the functional significance of the mast cell response associated with hyperplastic and neoplastic changes of skin remains to be elucidated.
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FIORE-DONATI, L., BENEDICTIS, G., CHIECO-BIANCHI, L. et al. Development of Mast Cell Reaction during Chemical Skin Carcinogenesis of Mouse. Nature 193, 287–288 (1962). https://doi.org/10.1038/193287a0
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DOI: https://doi.org/10.1038/193287a0
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