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Action of Mustard Gas on the Bone Marrow

Abstract

IN their article on “Biochemical Research on Chemical Warfare Agents”, Dixon and Needham1 refer to the work of Wormall and his co-workers2 on the distribution of mustard gas (H.) in the organs of rabbits which have been injected with a preparation of H. containing radioactive sulphur. It was found that the bone marrow contained only about one twentieth of the amount detected in the kidneys and lungs. Dixon and Needham go on to say: “It is surprising that marrow, the tissue most damaged, had the lowest H. content, while the two tissues with by far the highest H. content are practically undamaged by H. poisoning”. They then develop a theory to account for these findings.

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References

  1. Dixon, M., and Needham, D. M., Nature, 158, 432 (1946).

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  2. Boursnell, J. C., Francis, G. E., and Wormall, A., Rep. Chem. Defence Research Dept., Ministry of Supply (1942).

  3. Auerbach, C., and Robson, J. M., Rep. Chem. Defence Research Dept., Ministry of Supply (1942).

  4. Koller, P. C., Ansari, M. Y., and Robson, J. M., Rep. Chem. Defence Research Dept., Ministry of Supply (1943).

  5. Auerbach, C., and Robson, J. M., Proc. Roy. Soc. Edin., in the press.

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AUERBACH, C., ROBSON, J. Action of Mustard Gas on the Bone Marrow. Nature 158, 878–879 (1946). https://doi.org/10.1038/158878b0

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