Abstract
Experiments on striated muscle have been carried out at the EMBL Outstation at DESY, Hamburg, using the electron–positron storage ring DORIS as a high-intensity X-ray source. The low-angle reflections from the myosin cross-bridges could be recorded more than 1,000 times more rapidly than with the best conventional X-ray sources, and could be followed during contraction with a time resolution of 10 ms.
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References
Hanson, J. & Huxley, H. E. Symp. Soc. exp. Biol. 9, 228–264 (1955).
Huxley, A. F. Prog. Biophys. 7, 255–318 (1957).
Huxley, H. E. Proc. R. Soc. B141, 59 (1953).
Huxley, H. E. & Brown, W. J. molec. Biol. 30, 383–434 (1967).
Elliott, G. F., Lowy, J. & Millman, B. M. J. molec. Biol. 25, 31 (1967).
Huxley, H. E. J. molec. Biol. 37, 507–520 (1968).
Huxley, H. E. Cold Spring Harb. Symp. quant. Biol. 37, 361–376 (1972).
Haselgrove, J. C. & Huxley, H. E. J. molec. Biol. 77, 549–568 (1973).
Haselgrove, J. C. J molec. Biol. 92, 113–143 (1975).
Huxley, H. E. Ada anat. nippon. 50, 310–325 (1975).
Faruqi, A. R. IEEE. Trans. nuclSci. NS–22, 2066–2073 (1975).
Bond, C. & Faruqi, A. R. Nucl. Instr. Meth. 136, 383–388 (1976).
Huxley, H. E. & Haselgrove, J. C. in Myocardial Failure, 4–15 (Springer, Berlin, 1976).
Huxley, H. E. Cold Spring Harb. Cell Proliferation 3, 115–126 (1976).
Faruqi, A. R. & Huxley, H. E. J. appl. Crystallogr. 11, 449–454 (1978).
Huxley, H. E. in Cross-bridge Mechanism in Muscle Contraction (eds Sugi, H. & Pollack, G. H.) 391–401 (University of Tokyo Press, 1978).
Rosenbaum, G., Holmes, K. C. & Witz, J. Nature 230, 434–437 (1971).
Barrington–Leigh, J. & Rosenbaum, G. A. Rev. Biophys. Bioengng 5, 239–270 (1976).
Rosenbaum, G. & Harmsen, A. SSRL Rep. No. 78/04, VIII (eds Winick, H. & Brown, G.) 36–37 (Stanford Linear Accelerator Center, California).
Reynolds, G. T., Milch, J. R. & Gruner, S. M. Rev. sci. Instrum. 49, 1241–1249 (1978).
Milch, J. R. LE. E. E. Trans, nucl. Sci. 26, 338–345 (1979).
Gabriel, A. Rev. sci. Instrum. 48, 1303–1305 (1977).
Engster, C., Van Koningsveld, L. & Verweij, H. CERNRep. NP/1975-0620 (1975).
Clout, P. N., Bendall, P. J. & Golding, F. Proc. digital Equip. Comp. Users Soc. 5, 247–251 (1978).
Hendrix, J., Koch, M. H. J. & Bordas, J. J. appl. Crystallogr. 12, 467–472 (1979).
Lemonnier, M., Fourme, R., Rousseau, F. & Kohn, R. Nucl. Instrum. Meth. 152, 173–177 (1978).
Huxley, H. E. Science 164, 1356–1366 (1969).
Sugi, H., Amemiya, Y. & Hashizume, H., Japan Acad. 54(B), 559–564 (1978).
Matsubara, I. & Yagi, H. J. Physioi, Lond. 278, 297–307 (1978).
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Huxley, H., Faruqi, A., Bordas, J. et al. The use of synchrotron radiation in time-resolved X-ray diffraction studies of myosin layer-line reflections during muscle contraction. Nature 284, 140–143 (1980). https://doi.org/10.1038/284140a0
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DOI: https://doi.org/10.1038/284140a0
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