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Significance of Smoking in Investigations of Urinary Excretion Rates of Amines in Man

Nature volume 207, pages 200–201 (1965)Cite this article

Abstract

IN the determination of amphetamine (TR 9 min) by a gas–liquid chromatographic method1, an additional peak (TR 26 min) was observed in the extracts from urine of some but not all subjects; only subjects who smoked gave this latter peak. In smokers, large differences were observed in the ‘apparent amphetamine’ content of the urine determined by a methyl orange complexing method (using 1 : 2 dichloroethane as the extracting solvent, a solvent wash with borax pH 9.2 and measurements read at 540 mµ), and the amphetamine content determined by gas–liquid chromatography1 (Fig. 1).

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Authors and Affiliations

  1. School of Pharmacy, Chelsea College of Science and Technology, Manresa Road, London, S.W.3

    A. H. BECKETT, M. ROWLAND & E. J. TRIGGS

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  1. A. H. BECKETT
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  2. M. ROWLAND
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  3. E. J. TRIGGS
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BECKETT, A., ROWLAND, M. & TRIGGS, E. Significance of Smoking in Investigations of Urinary Excretion Rates of Amines in Man. Nature 207, 200–201 (1965). https://doi.org/10.1038/207200a0

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