Abstract
The 9,213-nucleotide structure of the AIDS/ lymphadenopathy virus has been determined from molecular clones representing the integrated provirus and viral RNA. The sequence reveals that the virus is highly polymorphic and lacks significant nucleotide homology with type C retroviruses characterized previously. Together with an analysis of the two major viral subgenomic RNAs, these studies establish the coding frames for the gag, pol and env genes and predict the expression of a novel gene at the 3′ end of the genome unrelated to the X genes of HTLV-I and -II.
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Gottlieb, M. et al. New Engl. J. Med. 305, 1425–1431 (1981).
Masur, H. et al. New Engl. J. Med. 305, 1431–1438 (1981).
Siegal, F. et al. New Engl. J. Med. 305, 1439–1444 (1981).
Seligman, M. et al. New Engl. J. Med. 311, 1286–1292 (1984).
Lane, H., Masur, H., Edgar, G., Whalen, G. & Fauci, A. New Engl. J. Med. 309, 453–458 (1983).
Ziegler, J. et al. New Engl. J. Med. 311, 565–570 (1984).
Barre-Sinoussi, F. et al. Science 220, 868 (1983).
Montagnier, L. et al. Human T-Cell Leukemia Viruses, 363–379 (Cold Spring Harbor Laboratory, New York, 1984).
Vilmer, E. et al. Lancet i, 753–757 (1984).
Popovic, M., Sarngadharan, M., Read, E. & Gallo, R. Science 224, 497–500 (1984).
Gallo, R. et al. Science 224, 500–503 (1984).
Feorino, P. et al. Science 225, 69–72 (1984).
Levy, J. et al. Science 225, 840–842 (1984).
Klatzmann, D. et al. Science 225, 59–63 (1984).
Schupbach, J. et al. Science 224, 503–505 (1984).
Sarngadharan, M., Popovic, M., Bruch, L., Schupbach, J. & Gallo, R. Science 224, 505–508 (1984).
Safai, B. et al. Lancet i, 1438–1440 (1984).
Brun-Vezinet, F. et al. Lancet i, 1253–1256 (1984).
Brun-Vezinet, F. et al. Science 226, 453–456 (1984).
Goedert, J. et al. Lancet ii, 711–715 (1984).
Lawrence, J. et al. New Engl. J. Med. 311, 1269–1273 (1984).
Schwartz, D., Zamecnik, P. & Weith, H. Proc. natn. Acad. Sci. U.S.A. 74, 994–998 (1977).
Haseltine, W., Maxam, A. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 989–993 (1977).
Shine, J. et al. Proc. natn. Acad. Sci. U.S.A. 74, 1473–1477 (1977).
Varmus, H. Science 216, 812–820 (1982).
Peters, G. & Glover, C. J. Virol. 35, 31–40 (1980).
Seiki, M., Hattori, S., Hirayama, Y. & Yoshida, M. Proc. natn. Acad. Sci. U.S.A. 80, 3618–3622 (1983).
Proudfoot, N. & Brownlee, G. Nature 252, 359–362 (1974).
Grosschedl, R. & Birnsteil, M. Proc. natn. Acad. Sci. U.S.A. 77, 1432–1436 (1980).
Kitchen, L. et al. Nature 312, 367–369 (1984).
Shinnick, T., Lerner, R. & Sutcliffe, J. Nature 293, 543–548 (1981).
Schwartz, D., Tizard, R. & Gilbert, W. Cell 32, 853–869 (1983).
Bolognesi, D., Luftig, R. & Schafer, J. Virology 56, 549–564 (1973).
Smith, B. & Bailey, J. Nucleic Acids Res. 7, 2055–2072 (1979).
Arya, S. et al. Science 225, 927–930 (1984).
Hahn, B. et al. Nature 312, 166–170 (1984).
Majors, J. & Varmus, H. J. Virol. 47, 495–504 (1983).
Perlman, D. & Halvorson, H. J. molec. Biol. 167, 394–409 (1983).
Montagnier, L. L. et al. Science 225, 63–66 (1984).
Haseltine, W. et al. Science 225, 419–421 (1984).
Shimotohno, K. et al. Proc. natn. Acad. Sci. U.S.A. 81, 6657–6661 (1984).
Weiss, S., Varmus, H. & Bishop, M. Cell 12, 983–992 (1977).
Mellon, P. & Duesberg, P. Nature 270, 631–634 (1977).
Cordell, B., Weiss, S., Varmus, H. & Bishop, M. Cell 15, 79–91 (1978).
Weiss, R., Teich, N., Varmus, H. & Coffin, J. RNA Tumor Viruses (Cold Spring Harbor Laboratory, New York, 1982).
Popovic, M. et al. Science 219, 856 (1983).
Sodrowski, J., Rosen, C. & Haseltine, W. Science 225, 381–385 (1984).
Chen, I., McLaughlin, J. & Golde, D. Nature 309, 276–279 (1984).
Keshet, E. & Temin, H. J. Virol. 31, 376–388 (1979).
Welier, S., Joy, A. & Temin, H. J. Virol. 33, 494–506 (1980).
Temin, H., Keshet, E. & Weller, S. Cold Spring Harbor Symp. quant. Biol. 44, 773–777 (1980).
Capon, D. et al. Nature 304, 507–513 (1983).
Wood, W. et al. Nature 312, 330–337 (1984).
Hyunh, T., Young, R. & Davis, R. in Practical Approaches to Biochemistry (ed. Groves, D.) (IRL, Oxford, in the press).
Benton, W. & Davis, R. Science 196, 180–182 (1977).
Foley, G. et al. Cancer 18, 522–529 (1965).
Mullins, J., Brody, D., Binari, R. & Cotter, S. Nature 308, 856–858 (1984).
Southern, E. J. molec. Biol. 98, 503–517 (1975).
Taylor, J., Illmensee, R. & Summer, S. Biochim. biophys. Acta 442, 324–330 (1976).
Maniatis, T., Fritsch, E. & Sambrook, J. Molecular Cloning (Cold Spring Harbor Laboratory, New York, 1982).
Messing, J., Crea, R. & Seeburg, P. Nucleic Acids Res. 9, 309–321 (1981).
Sanger, F. et al. J. molec. Biol. 143, 161–178 (1980).
Kyte, J. & Doolittle, R. J. molec. Biol. 157, 105–132 (1982).
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Muesing, M., Smith, D., Cabradilla, C. et al. Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirus. Nature 313, 450–458 (1985). https://doi.org/10.1038/313450a0
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DOI: https://doi.org/10.1038/313450a0
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