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Binding studies with3H-atropine in intact isolated guinea pig gastric mucosal cells

  • Histamine and Kinins
  • Histamine and the Gastrointestinal Tract
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Abstract

3H-atropine binding was studied in isolated intact guinea pig gastric mucosal cells and has been shown to be saturable. Scatchard plots of the binding system calculated under the assumption of only one binding site revealedK D values for the parietal cell enriched population of 1.25×10−6 mol/l and 1.38×10−6 mol/l for the nonparietal cells. The results show that in the gastric mucosa both parietal and nonparietal cells contain cholinergic receptors.

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References

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Authors and Affiliations

  1. Department of Pharmacology, University of Tübingen, D-7400, Tübingen, Germany

    M. Albinus & K. -Fr. Sewing

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  1. M. Albinus
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  2. K. -Fr. Sewing
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Albinus, M., Sewing, K.F. Binding studies with3H-atropine in intact isolated guinea pig gastric mucosal cells. Agents and Actions 10, 192–194 (1980). https://doi.org/10.1007/BF02024212

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  • DOI: https://doi.org/10.1007/BF02024212

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