Abstract
MCD-peptide and its modified analogues have been tested for their histamine-releasing activity on mast cells and for the ability to inhibit vascular permeability in rat's skin. Reduction of disulphide bonds, modification of the basic lysine ɛ-NH2 groups and histidines in MCD-peptide suppressed its histamine-releasing action. Modification of the basic arginine guanidino groups did not alter this activity. MCD-peptide inhibited the vascular permeability induced by histamine and serotonin. Modification of MCD-peptide lysines and arginines abolished the inhibiting activity.
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Gushchin, I.S., Miroshnikov, A.I., Martynov, V.I. et al. Histamine releasing and anti-inflammatory activities of MCD-peptide and its modified forms. Agents and Actions 11, 69–71 (1981). https://doi.org/10.1007/BF01991459
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DOI: https://doi.org/10.1007/BF01991459