Abstract
Broncoconstriction in the guinea-pig due to leukotrienes C4 and D4in vivo andin vitro was suppressed by aspirin. Since contracting effects of putative mediators of bronchial asthma should be refractory to inhibition of cyclooxygenase, our results indicate that release of leukotrienes in the guinea-pig does not alone account for anaphylactic bronchoconstriction.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J.R. Vane, Prostaglandins in the inflammatory response. InInflammation: ‘Mechanisms and Control’ (EdsI.H. Lepow andP.A. Ward) Academic Press, New York and London 1972.
M.B. Zucker andJ. Peterson,Inhibition of adenosine diphosphate induced secondary aggregation and other platelet functions by acetylsalicyclic acid ingestion, Proc. Soc. Exp. Biol. (N.Y.)127, 547–551 (1968).
C.H. Kellaway andE.R. Trethewie,The liberation of a slow-reacting smooth muscle-stimulating substance in anaphylaxis, Q. J. Exp. Physiol.30, 121–145 (1940).
J.M. Drazen, K.F. Austen, R.A. Lewis, D.A. Clark, G. Goto, A. Marfat andE.J. Corey,Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro, Proc. Natn. Acad. Sci. USA77, 4354–4358 (1980).
P.A. Berry andH.O.J. Collier,Bronchoconstrictor action and antagonism of a slow-reacting substance from anaphylaxis of guinea-pig isolated lung, Br. J. Pharmac. Chemother.23, 201–216 (1964).
B.B. Vargaftig, J. Lefort, A.V. Prancan, M. Chignard andJ. Benveniste,Platelet-lung in vivo interactions: an artifact or a multipurpose model? Haemostasis8, 171–182 (1979).
B.B. Vargaftig, M. Chignard, J.M. Mencia-Huerta, B. Arnoux andJ. Benveniste, Pharmacology of arachidonate metabolites and of platelet-activating factor (PAF-acether). InPlatelets in Biology and Pathology, vol. 2. (Ed.J. Gordon) Elsevier/North Holland Biomedical Press 1981.
J. Lefort andB.B. Vargaftig Role of platelets in aspirin-sensitive bronchoconstriction in the guinea-pig; interactions with salicylic acid, Br. J. Pharmac.63, 35–42 (1978).
K.M. Lulich, M.W. Mitchell andM.P. Sparrow,The cat lung strip as an in vitro preparation peripheral airways: A comparison of β-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea, Br. J. Pharmac.58, 71–79 (1976).
B.B. Vargaftig andN. Dao,Release of vasoactive substances from quinea-pig lungs by slow reacting substance C and arachidonic acid, Pharmacology6, 99–108 (1971).
B.B. Vargaftig, Interference of anti-inflammatory drugs with hypotension. InHandbook of Experimental Pharmacology, vol. 50 (EdsJ.R. Vane andS.H. Ferreira) Springer Verlag, Berlin, Heidelberg 1978.
D.M. Engineer, P.J. Piper andP. Sirois,Interaction between the release of SRS-A and of prostaglandins, Br. J. Pharmac.57, 460–461 (1976).
P.J. Piper andJ.R. Vane,Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs, Nature (London)223, 20–35 (1969).
F. Al-Ubaidi andY.S. Bakhle,Differences in biological activation of arachidonie acid in perfused lungs from guinea-pig, rat and man, Eur. J. Pharmac.62, 89–96 (1980).
BB. Vargaftig, J. Lefort, M. Chignard andJ. Benveniste,Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives, Eur. J. Pharmac.65, 185–192 (1980).
M. Joseph, A.B. Tonnel, A. Capron andJ.P. Dessaint,The interaction of IgE antibody with human alveolar macrophages and its participation in the inflammatory processes of lung allergy, Agents and Actions11, 619–622 (1981).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vargaftig, B.B., Lefort, J. & Murphy, R.C. Leukotrines C and D induce aspirin-sensitive bronchoconstriction in the guine-pig. Agents and Actions 11, 574–576 (1981). https://doi.org/10.1007/BF01978747
Issue Date:
DOI: https://doi.org/10.1007/BF01978747