Skip to main content
Log in

Effect of inflammatory arthritis on dexamethasone receptors in phagocytes—a possible role for plasma factors

  • Proceedings of the 3rd European Workshop on Inflammation, Paris, 2–3 March 1981
  • Inflammation Revisited: Cellular Aspects
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Synovial tissue cells from patients with seropositive rheumatoid arthritis bind dexamethasone in a similar fashion to the classical steroid receptors on other cells. In contrast, synovial fluid cells and blood PMNLs from these patients bind dexamethasone with much reduced affinity. Some component of plasma may interfere with the binding of dexamethasone to its receptor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Z. Werb, R. Foley andA. Munck, J. Exp. Med.147, 1684–1694 (1979).

    Article  Google Scholar 

  2. I.P. Braidman, K. Collins, C. Jones, K. Morris andM. Jayson, Agents and Actions7, 233–236 (1980).

    PubMed  Google Scholar 

  3. H.E. Rosenthal, Analyt. Biochem.20, 252–232 (1967).

    Google Scholar 

  4. G. Scatchard, Ann. N.Y. Acad. Sci.57, 660–672 (1949).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Braidman, I.P., Livingston, K., Tomlinson, I.W. et al. Effect of inflammatory arthritis on dexamethasone receptors in phagocytes—a possible role for plasma factors. Agents and Actions 11, 602–604 (1981). https://doi.org/10.1007/BF01978758

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01978758

Keywords

Navigation