Skip to main content
SpringerLink
Log in

Local histamine release after immunological and non-immunological mast cell degranulationin vivo

  • Histamine Release and Pathological States
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Plasma histamine concentration in the circulation has been proposed as an index of mast cell degranulation occurringin vivo but there are problems with this approach in practice. Local elevations in plasma histamine occur in blood draining the site of antigen challenge in forearm skin. We have compared changes in plasma histamine concentration with time following intradermal injection of antigen, codeine or histamine to produce matched wheal and flare responses in 4 atopic subjects. Less histamine appears to be released after non-immunological challenge.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M.J. Brown, P.W. Ind, R. Causon andT.H. Lee,A novel double-isotope technique for the enzymatic assay of plasma histamine: application to estimation of mast cell activation assessed by antigen challenge in asthmatics, J. Allergy Clin. Immunol.69, 20–24 (1982).

    PubMed  Google Scholar 

  2. P.W. Ind, P.J. Barnes, M.J. Brown, R. Causon andC.T. Dollery,Measurement of plasma histamine in asthma, Clin. Allergy13, 61–67 (1983).

    PubMed  Google Scholar 

  3. D.J. Heavey, P.W. Ind, A. Miyatake andC.T. Dollery,Local histamine release in man following intradermal antigen challenge, Br. J. Clin. Pharmacol. (1983, in press).

  4. E.H. Dunsky andB. Zweiman,The direct demonstration of histamine release in allergic reactions in the skin using a skin chamber technique, J. Allergy Clin. Immunol.62, 127–130 (1978).

    PubMed  Google Scholar 

  5. S. Ting, E.H. Dunsky, R. Lavker andB. Zweiman,Patterns of mast cell alterations and in vivo mediator release in human allergic reactions, J. Allergy Clin. Immunol.66, 417–423 (1980).

    Article  PubMed  Google Scholar 

  6. P.W. Ind, M.J. Brown, I.M. Macquin, F.J.M. Lhoste andC.T. Dollery,Concentration effect relationships of infused histamine in normal volunteers, Agents and Actions12, 12–16 (1982).

    Article  PubMed  Google Scholar 

  7. W. Lorenz, A. Doenicke, B. Schoning andE. Neugebauer, The role of histamine in adverse reactions to intravenous agents. InAdverse Reactions of Anaesthetic Drugs, pp. 169–238 (Ed. A. Thornton). Elsevier/North Holland, Biomedical Press, 1981.

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology, Royal Postgraduate Medical School, Ducane Road, W12 OHS, London, UK

    P. W. Ind, A. Miyatake, D. J. Heavey & C. T. Dollery

Authors
  1. P. W. Ind
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Miyatake
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. J. Heavey
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. T. Dollery
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ind, P.W., Miyatake, A., Heavey, D.J. et al. Local histamine release after immunological and non-immunological mast cell degranulationin vivo . Agents and Actions 14, 417–419 (1984). https://doi.org/10.1007/BF01973841

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01973841

Keywords

Search

Navigation