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Pharmacokinetic study of3H-labelled PAF-acether II. Comparison with3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding

  • Platelets and Thrombosis
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Abstract

The blood and plasma kinetics of intravenously administered3H-labelled PAF-acether were determined in seven rabbits. PAF-acether was rapidly distributed and slowly eliminated. Individual variations were very small.

The main route of metabolism involves deacetylation of the PAF-acether into lyso-PAF-acether, leading to an equilibrium between the two molecules (10%/90%). This equilibrium, observed within 30 minutes, was still the same after 6 hours suggestingin vivo reacetylation of lyso-PAF-acether into PAF-acether. However, this could not be verified.

After intravenous administration of lyso-PAF-acether in two rabbits, PAF-acether could not be found in any blood sample. The pharmacokinetic behaviour of both PAF-acether and lyso-PAF-acether can be described by a three-compartment model.

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Lartigue-Mattei, C., Godeneche, D., Chabard, J.L. et al. Pharmacokinetic study of3H-labelled PAF-acether II. Comparison with3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. Agents and Actions 15, 643–648 (1984). https://doi.org/10.1007/BF01966786

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