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Non-invasive assessment of electrophysiological effects of histamine infusion in mam

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Abstract

The electrophysiological changes induced by sequential infusion of histamine (H) (0.4 and 1.0 mcg/kg/min for 10 min each) were investigated by conventional ECG and High Resolution ECG (H.R.ECG). The latter permits external non-invasive recording of the potentials generated in the cardiac conduction system. H was infused i.v. in 5 normal volunteers with a mean age of 30 years. H infusions were begun with 0.4 mcg/kg/min and continued for 10 min. After a 60 min recovery period a second 10 min infusion (1 mcg/kg/min) was administered. In man H produced a dose-dependent increase in heart rate, a significant depression of the ST-T complex, and a depression in STJ point. The QRS complex duration was unmodified. H.R.ECG showed significant changes in the morphology and voltage of the atrial activity. The electrophysiological effects disappeared within a few minutes after discontinuing the infusions of H.

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Authors and Affiliations

  1. Department of Medicine, University of Naples-II School of Medicine, Via S. Pansini 5, 80131, Naples, Italy

    A. Genovese, L. Adinolfi, S. Quattrin, A. Accinni, G. Spadaro, I. Dote & G. Marone

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  1. A. Genovese
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  2. L. Adinolfi
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  3. S. Quattrin
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  4. A. Accinni
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  5. G. Spadaro
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  6. I. Dote
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  7. G. Marone
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Genovese, A., Adinolfi, L., Quattrin, S. et al. Non-invasive assessment of electrophysiological effects of histamine infusion in mam. Agents and Actions 17, 42–45 (1985). https://doi.org/10.1007/BF01966679

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  • DOI: https://doi.org/10.1007/BF01966679

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