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Anaphylactoid reactions and histamine release do not occur after application of the opioid tramadol

  • Pathophysiological Role of Histamine and Clinical Aspects
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Abstract

After an i.v. application of 100 mg tramadol in 13 healthy volunteers (1) no change in plasma histamine concentration could be detected, (2) systemic anaphylactoid reactions did not occur, (3) cutaneous reactions were not rated as anaphylactoid since itching and erythema were seen only once after tramadol whereas erythema was also observed twice after saline, (4) blood pressure and heart rate were only very slightly and transiently elevated without any abnormalities in ECG-readings and (5) only side effects typical for opioid therapy were observed.

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Authors and Affiliations

  1. Gruenenthal GmbH, Center of Research, Zieglerstr. 6, D-5100, Aachen

    H. Barth, H. Giertz, A. Schmal & W. Lorenz

  2. Institute of Theoretical Surgery, Operative Center I, University of Marburg, Baldingerstraße, D-3550, Marburg, Federal Republic of Germany

    H. Barth, H. Giertz, A. Schmal & W. Lorenz

Authors
  1. H. Barth
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  2. H. Giertz
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  3. A. Schmal
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  4. W. Lorenz
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Barth, H., Giertz, H., Schmal, A. et al. Anaphylactoid reactions and histamine release do not occur after application of the opioid tramadol. Agents and Actions 20, 310–313 (1987). https://doi.org/10.1007/BF02074699

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