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Roles of kallikrein-kinin system in acute inflammation: Studies on high- and low-molecular weight kininogens-deficient rats (B/N-Katholiek strain)

  • Mediators of Acute Inflammation
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Abstract

Carrageenin-induced paw edema in HMW- and LMW-kininogens-deficient rats was significantly less than that in normal rats. There are three kiniogens, HMW-, LMW- and T-kininogens, in normal rat plasma, but B/N-Katholiek rat plasma contains only T-kininogen. The pretreatment with captopril, a kiniase II inhibitor, enhanced paw swelling of normal rats, but not that of the deficient rats, indicating that bradykinin released from HMW-kininogen may have a role for the swelling but T-kinin may not be released in this inflammation.

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Authors and Affiliations

  1. Department of Pharmacology, School of Pharmac. Sci., Kitasato University, 5-9-1 Shirokane, Minatoku, 108, Tokyo

    S. Oh-ishi, I. Hayashi, I. Utsunomiya, M. Hayashi, K. Yamaki & A. Yamasu

  2. School of Medicine, 228, Sagamihara, Japan

    T. Nakano

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  1. S. Oh-ishi
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  2. I. Hayashi
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  3. I. Utsunomiya
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  4. M. Hayashi
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  5. K. Yamaki
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  6. A. Yamasu
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  7. T. Nakano
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Oh-ishi, S., Hayashi, I., Utsunomiya, I. et al. Roles of kallikrein-kinin system in acute inflammation: Studies on high- and low-molecular weight kininogens-deficient rats (B/N-Katholiek strain). Agents and Actions 21, 384–386 (1987). https://doi.org/10.1007/BF01966523

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  • DOI: https://doi.org/10.1007/BF01966523

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