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Increased histidine decarboxylase (HDC) activity in human colorectal cancer: Results of a study on ten patients

  • Histamine in Pathophysiology and Clinical Studies
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Abstract

Following numerous reports of high histidine decarboxylase (HDC) activity in tumour-bearing animals, the present work was designed to determine the activity of this enzyme in normal and tumour tissues in a series of ten surgical patients with colorectal carcinoma.

Significantly increased HDC activity, almost double that of normal tissues, was found in specimens from extirpated human tumours. These results, obtained under reliable sampling and measurement conditions indicated that changes in the enzymic activity of HDC may have a significant role in the development of colorectal tumour cells. Inhibition of the enzyme activity in human cancer subjects may retard or impede tumour growth and perhaps limit the spread of metastases.

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References

  1. D. Mackay, P. B. Marshall and J. F. Riley,Histidine decarboxylase activity in a malignant rat hepatoma, J. Physiol.31P, 153–156 (1960).

    Google Scholar 

  2. G. Kahlson and E. Rosengren,Histamine: entering physiology, Experientia20, 291–294 (1987).

    Google Scholar 

  3. H. Nolte, P. Stahl Skov and H. Loft,Stimulation of histamine synthesis from tumour cells by concanavalin A and A23187, Agents and Actions20, 291–294 (1987).

    Article  PubMed  Google Scholar 

  4. P. Scheinmann, B. Lebel, N. R. Lynch, J. C. Salomon, J. R. Paupe and C. Burtin,Histamine levels in blood and other tissues of male and female C 3H mice. II. Mice carrying a 3-methyl-cholanthrene-induced tumour, Agents and Actions9, 95–96 (1979).

    Article  PubMed  Google Scholar 

  5. C. Burtin, P. Scheinmann, K. C. Salamon, G. Lespinats and P. Canu,Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H 1 and H2 histamine receptors, Br. J. Cancer45, 54–60 (1982).

    PubMed  Google Scholar 

  6. J. Bartholeyns and M. Bouclier,Involvement of histamine in growth of mouse and rat tumours; antitumoral properties of monofluoromethyl histamine, an enzyme-activated irreversible inhibitor of histidine decarboxylase, Cancer Research44, 639–645 (1984).

    PubMed  Google Scholar 

  7. D. Kierska, K. Sasiak, T. Bieganski and Cz. Maslinski,Causal relationship between a tumour growth and the changes in histamine methabolism in tissues of sacroma-bearing rat, Agents and Actions20, 314–316 (1987).

    Article  PubMed  Google Scholar 

  8. M. Osband, Y.-J. Shen, M. Schlesinger, A. Brown, D. Hamilton, E. Cohen, P. Lavin and R. Mc Caffrey,Successful tumour immunotherapy with cimetidine in mice, Lanceti, 636–638 (1981).

    Article  Google Scholar 

  9. A. J. Scolnick, M. C. Rubio, L. L. Colombo, R. R. Comoli and R. A. Caro,Further studies on the histamine metabolism in the M-2 adenocarcinoma. Biomedicine and Pharmacotherapy38, 465–467 (1984).

    Google Scholar 

  10. E. Neugebauer and W. Lorenz,A modified Schayer procedure for the estimation of histidine decarboxylase activity: its application on tissue extracts from gastric mucosa of various mammals. Agents and Actions12, 32–40 (1982).

    Article  PubMed  Google Scholar 

  11. J. Kusche, T. Bieganski, R. Hesterberg, C.-D. Stahlknecht, K.-D. Feußner, I. Stahlenberg and W. Lorenz,The influence of carcinoma growth on diamine oxidase activity in the human gastrointestinal tract, Agents and Actions10, 110–113 (1980).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. I Catedra Cirugia, Universidad de Malaga, 29080, Malaga, Spain

    M. Garcia-Caballero, R. Campos & C. Vara-Thorbeck

  2. Institute for Theoretical Surgery, Centre Operative Medicine I, Philipps-University Marburg, Baldingerstraße, D-3550, Marburg, FRG

    E. Neugebauer

  3. Departmento de Bioquimica, Facultad de Ciencias, Universidad de Malage, 29080, Spain

    I. Nunez de Castro

Authors
  1. M. Garcia-Caballero
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  2. E. Neugebauer
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  3. R. Campos
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  4. I. Nunez de Castro
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  5. C. Vara-Thorbeck
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Additional information

This paper is part of a joint project between the University of Malaga and the Philipps-University of Marburg.

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Garcia-Caballero, M., Neugebauer, E., Campos, R. et al. Increased histidine decarboxylase (HDC) activity in human colorectal cancer: Results of a study on ten patients. Agents and Actions 23, 357–360 (1988). https://doi.org/10.1007/BF02142587

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  • DOI: https://doi.org/10.1007/BF02142587

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