Abstract
When low frequency electrical stimulations were repeatedly applied to the rat midbrain reticular formation, the EEG spectral power recorded at the cortex and thalamus increased markedly, especially in the low frequency bands (0–6 Hz). The intraventricular administration of histamine (Hi) inhibited this increase. Hi-induced inhibition was antagonized by simultaneous injection of an equimolar dose of either pyrilamine or diphenhydramine, but not by that of cimetidine. In accordance with this, 2-methylHi decreased the power in the slow wave region, while 4-methylHi was not effective. It was assumed that the EEG arousal effect of Hi is exerted via H1 receptors but not related to H2 receptors. Adverse effects of H1 blockers on the brain, such as drowsiness, may be produced as a consequence of this inhibitory action.
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References
W. Feldberg and S. L. Sherwood,Injections of drugs into the lateral ventricle of the cat. J. Physiol.123, 148–167 (1954).
C. Kamei, H. Akahori and K. Tasaka,Influence of histamine and related compounds on the hypnotic effect of thiopental in mice. J. Pharmacobio-Dyn.9, 112–116 (1986).
M. Monnier, R. Sauer and A. H. Hatt,The activating effect of histamine on the central nervous system. Int. Rev. Neurobiol.12, 265–305 (1970).
P. W. Kalivas,Histamine-induced arousal in the conscious and pentobarbital pretreated rat. J. Pharmacol. exp. Ther.222, 37–42 (1982).
J. W. Cooley and J. S. Tukey,An algorithm for the machine calculation of complex Fourier series. Math. Comput.19 267–301 (1965).
H. H. Jasper,Unspecific thalmo-cortical relations, InHandbook of Physiology II. (Eds. J. Field, H. W. Mogoun and V. E. Hill) pp. 1307–1321, Am. Physiol. Soc., Washington 1960.
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Tasaka, K., Chung, Y.H. & Sawada, K. Excitatory effect of histamine on EEGs of the cortex and thalamus in rats. Agents and Actions 27, 127–130 (1989). https://doi.org/10.1007/BF02222218
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DOI: https://doi.org/10.1007/BF02222218