Skip to main content
SpringerLink
Log in

Evidence of free radical (FR) involvement in ischemic colitis

  • Mediation of Inflammatory Process
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Early ischemic colitis was induced in rats to evaluate the roles of FRs and intraluminal content. After 30 minutes of ischemia, biopsies for histology, conjugated dienes (CD) and malonaldehyde (M), presumptive marker of lipid peroxidation, were obtained at 0, 30, and 60 minutes reperfusion. Histology was unchanged. CD and M were elevated in ischemic and saline controls, and rose progressively during reperfusion; CD and M were essentially the same as non-ischemic controls during reperfusion with intraluminal corticosteroid (c) and Alcide (A). These agents may be beneficial in early ischemic colitis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D. A. Parks, G. B. Buckley, D. N. Granger, S. R. Hamilton and J. M. McCord,Ischemic injury in cat small intestine: Role of superoxide radicals. Gastro. Enterology82, 9–15 (1982).

    Google Scholar 

  2. J. A. Buese and S. D. Aust,Microsomal lipid peroxidation. Methods in Enzymology,52, 302–310 (1978).

    Google Scholar 

  3. M. C. Dalsing, J. L. Grosfeld, M. A. Shiffler, D. W. Vane, M. Hull, R. C. Baehner and T. R. Weber,Superoxide dismutase: A cellular protective enzyme in bowel ischemia. J. Surg. Res.34, 589–596 (1983).

    Google Scholar 

  4. J. W. L. Robinson and V. Mirkovitch,The roles of intraluminal oxygen and glucose in the protection of the rat intestinal mucosa from the effects of ischemia. Biomed.27, 60–62 (1977).

    Google Scholar 

  5. B. Grøgaarad, D. A. Parker, D. N. Granger, J. M. McCord and J. O. Forsberg,Effects of ischemia and oxygen radicals on mucosal albumin clearance in intestine. Am. J. Physiol.242, 6448–6454 (1982).

    Google Scholar 

  6. T. S. Griffen and P. F. Hagihara,Ischemic colitis in rats. Dis. Colon. Rectum25, 638–640 (1982).

    Google Scholar 

  7. D. M. Douglas, J. C. Russell and D. K. Das,Mechanism of action of a potential wound-healing compounds, alcide. Second International Symposium on Tissue Repair: Biological and Chemical Aspects, Targon Springs, FL 1987.

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, University of Connecticut School of Medicine, 06032, Farmington, CT, USA

    D. M. Douglas, J. C. Russell, D. Goren, S. Dempsey & D. K. Das

Authors
  1. D. M. Douglas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. C. Russell
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Goren
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Dempsey
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. K. Das
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Douglas, D.M., Russell, J.C., Goren, D. et al. Evidence of free radical (FR) involvement in ischemic colitis. Agents and Actions 27, 435–437 (1989). https://doi.org/10.1007/BF01972844

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01972844

Keywords

Search

Navigation