Abstract
Bucillamine [SA96: N-(2-mercapto-2-methylpropanoyl)-l-cysteine], a synthetic SH compound, has recently been developed as remission-inducing agent for rheumatoid arthritis (RA), and its clinical usefulness for RA has been proved in Japan. Bucillamine suppressed the mitogen-induced proliferation of murine lymphocytesin vitro. The present study was undertaken to clarify the effect of bucillamine primarily on the release of interleukin (IL)-1 from monocytes and on the proliferation of T cells. Bucillamine significantly inhibited IL-1-induced thymocyte proliferation in a dose-dependent manner. And, bucillamine also inhibited IL-2-induced proliferation at the concentration of 1×10−4 M, but augmented proliferation at the concentration of 1×10−5 M. In contrast,d-penicillamine (an analogous SH compound to bucillamine) did not show any significant effect at similar concentrations.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. Ooya, J. Matsumoto, H. Takashina, T. Watanabe and J. Iwao,Thiol compound (II). Synthesis and anti-hypertensive activity of mercaptoacylamino acids. Chem. Pharma. Bull.29, 940 (1981).
H. Fujimura, Y. Hiramatsu, Y. Tamura, M. Yanagihara, A. Koda, H. Nagai, K. Uda, T. Iso and H. Yamauchi,Pharmacological studies of new sulfhydryl compounds 2-mercapto-2-methylpropanoyl- l-cysteine (SA96). I.Evaluation of antirheumatic action. Folia pharmacol. japon.76, 117–129 (1980).
Y. Shiokawa, N. Ogawa, C. Abe, S. Kosaka, M. Homma, M. Akizuki, T. Kageyama, Y. Mizushima, S. Sugahara and K. Shichikawa,New antirheumatic SA96 on rheumatoid arthritis. Japan. J. Inflammation6, 409–430 (1986).
I. Yamamoto, H. Ohmori and T. Okimura,SA96: Immunopharmacological profile in vitro. Int. J. Tiss. Reac.4, 1–8 (1982).
C. Abe,Clinical evaluation of immunomodulators. Int. J. Immunotherapy1, 7–10 (1985).
E.-L. Larsson, N. N. Iscove and A. Coutinho,Two distinct factors are required for induction of T cell growth. Nature283, 664 (1980).
D. S. Synder and E. R. Unanue,Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production. J. Immunol.129, 1803–1805 (1982).
M. Brisset, J.-P. Pujol, F. Arenzana-Seisdedos, J.-L. Virelizier, H. Penfornis, J. Farjanel, A. Rattner, J. Bocquet, R. Beliard and G. Loyau,d-Penicillamine inhibition of Interleukin-1 production: A possible mechanism for its effect on synovial collagen synthesis? Int. J. Tiss. Reac.8, 279–287 (1986).
K. Nakata, H. Suda, H. Yamauchi and T. Iso,Pharmacological studies of N-(2-mercapto-2-methylpropanoyl)- l-cysteine (SA96). (3) Effects of SA96 on experimental allergic reactions. Japan. J. Pharmacol.37, 85–90 (1985).
N. Morikawa, J. Matsumoto, H. Kito and T. Iso,Metabolic fate of N-(2-mercapto-2-methylpropionyl)- l-cysteine (SA96). (II) Absorption, distribution, metabolism and excretion during repeated administrations to male rats. IYAKUHIN KENKYU16, 808–817 (1985).
S. B. Mizel, J. M. Dayer, S. M. Krane and S. E. Mergenhagen,Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin-1). Proc. Natl. Acad. Sci. USA.78, 2474 (1981).
R. L. Johnson and M. Ziff,Lymphokine stimulation of collagen accumulation. J. Clin. Invest.58, 240 (1976).
S. A. Jimenez, W. McArthur and J. Rosenbloom,Inhibition of collagen synthesis by mononuclear cell supernates. J. Exp. Med.150, 1421 (1979).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sasano, M., Goto, M. & Nishioka, K. Modulatory effect of bucillamine (SA96) on interleukin-1-and/or-2-induced proliferation of T lymphocytes. Agents and Actions 31, 285–289 (1990). https://doi.org/10.1007/BF01997621
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01997621