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The action of a calcitonin gene-related peptide antagonist in human skin

  • Histamine Release from Mast Cells and Basophils
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Abstract

The CGRP antagonist, CGRP8-37, antagonized the ability of CGRP to increase blood flow in human skin and cause erythema. The mechanism of the antagonist effect of CGRP8-37 on the CGRP-induced erythema was an increase by the antagonist of the rate of decay of the CGRP-induced erythema. Since CGRP8-37 activates rat peritoneal mast cells to release their granular contents, we conclude that the degradation of CGRP by protease released from skin mast cells by CGRP8-37. It was not possible to demonstrate any antagonistic effect of CGRP8-37 on the CGRP receptor mediating increased blood flow in human skin.

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Authors and Affiliations

  1. Department of Pharmacology, The School of Medicine, University College London, Gwer Street, WC1E 6BT, London, UK

    N. A. Hayes, I. Marshall &  J. C. Foreman

  2. Department of Dermatology, The School of Medicine, University Colleg London, Gower Street, WC1E 6BT, London, UK

    C. B. Bunker & P. M. Dowd

Authors
  1. N. A. Hayes
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  2. C. B. Bunker
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  3. I. Marshall
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  4. P. M. Dowd
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  5. J. C. Foreman
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Hayes, N.A., Bunker, C.B., Marshall, I. et al. The action of a calcitonin gene-related peptide antagonist in human skin. Agents and Actions 38, C212–C214 (1993). https://doi.org/10.1007/BF01996463

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