Abstract
The mast cell protective effects of the newly developed long-actingβ 2-adrenergic salmeterol and formoterol were compared with those of conventionally usedβ 2-adrenergic, non-specific β-agonists, disodium cromoglycate (DSCG) and theophylline. With the exception of DSCG, all the test agents inhibited ovalbumin-induced histamine release from enzymically dispersed guinea pig lung mast cells in a dose-dependent fashion. At the maximum concentration tested, theophylline produced the highest level of protection, inhibiting up to 90% of ovalbumin-induced histamine release whereas DSCG produced only 10% inhibition. The maximum inhibition produced by all theβ 2-adrenergic tested was around 45%. While salmeterol was equipotent with salbutamol, formoterol was at least a 100-fold more potent. Hence the present study confirmed the previously reported mast cell stabilizing actions of conventionalβ 2-adrenergic and extended the observation to the newly developed long-acting analogues.
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Lau, H.Y.A., Wong, P.L. & Lai, C.K.W. Effects ofβ 2-adrenergic agonists on isolated guinea pig lung mast cells. Agents and Actions 42, 92–94 (1994). https://doi.org/10.1007/BF01983471
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DOI: https://doi.org/10.1007/BF01983471