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Effects of cyclosporin on serum hyaluronan levels in collagen arthritis

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Abstract

Serum hyaluronan (HA) levels were measured in a rat model of collagen arthritis using a sandwich enzyme-linked immunosorbent assay. Values became elevated as the arthritis developed, correlating with its severity. Daily subcutaneous treatment with cyclosporin at the dose of 25 mg/kg per day for fourteen days completely prevented anti-type II collagen antibody production and the serum HA increase as well as development of collagen arthritis. HA in the blood may thus provide a good quantitative marker for joint disease in rat collagen arthritis with potential as a tool for evaluation of drug efficacy in this experimental model.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, School of Medicine, Kitasato University, 1-15-1, Kitasato, 228, Sagamihara, Kanagawa, Japan

    K. Takagishi & M. Itoman

  2. Department of Biochemistry, School of Medicine, Kitasato University, 1-15-1, Kitasato, 228, Sagamihara, Kanagawa, Japan

    Y. Goso

  3. Department of Pathology, School of Medicine, Kitasato University, 1-15-1, Kitasato, 228, Sagamihara, Kanagawa, Japan

    S. Kuwao

  4. Department of Orthopedic Surgery, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, 812, Fukuoka, Japan

    H. Miyahara

  5. Kaibara Orthopedic Hospital, 8-20, Gion-machi, Hakata-ku, 812, Fukuoka, Japan

    N. Kaibara

Authors
  1. K. Takagishi
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  2. M. Itoman
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  3. Y. Goso
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  4. S. Kuwao
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  5. H. Miyahara
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  6. N. Kaibara
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Takagishi, K., Itoman, M., Goso, Y. et al. Effects of cyclosporin on serum hyaluronan levels in collagen arthritis. Inflamm Res 44, 79–82 (1995). https://doi.org/10.1007/BF01793217

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  • DOI: https://doi.org/10.1007/BF01793217

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