Abstract.
Objective: To examine the effect of hyaluronic acid (HA) on the induction of superoxide anion by IL-1 in chondrocytes. ¶Materials and Methods: Bovine articular chondrocytes were treated with different concentrations of IL-1. A chemiluminescent probe (L-012) was added to the medium and chemiluminescence detection was used to measure superoxide anion. ¶Results: IL-1 caused induction of superoxide anions in a dose-dependent manner. HA (10–100 <mu>g/ml) countered superoxide induction caused by 20 ng/ml of IL-1. ¶Conclusion: HA can afford protection against cartilage degradation, probably acting as a free-radical scavenger.
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Received 7 July 1996; returned for revision 13 August 1996; returned for final revision 16 December 1996; accepted by W. B. van den Berg 16 January 1997
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Fukuda, K., Takayama, M., Ueno, M. et al. Hyaluronic acid inhibits interleukin-1-induced superoxide anion in bovine chondrocytes. Inflamm. res. 46, 114–117 (1997). https://doi.org/10.1007/s000110050132
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DOI: https://doi.org/10.1007/s000110050132