Abstract
Objective and Design: In the present study, the involvement of the binding of IHRP (inter-alpha-trypsin inhibitor family heavy chain-related protein) and actin in phagocyte activity was investigated.¶Materials and Methods: The actin polymerization and the phagocytic activity of the polymorphonuclear (PMN) cells were studied in the presence of IHRP.¶Results: IHRP inhibited the polymerization of actin and the phagocytic activity of the PMN cells.¶Conclusion: 1) IHRP may bind to actin released from the damaged cells and suppress its toxic action by preventing the formation of actin fibril. 2) IHRP may bind to cell surface actin on PMN cells and inhibit their phagocytic activities. 3) From these results, IHRP may act as an anti-inflamma-tory protein.
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Received 20 November 1999; returned for revision 20 December 1999; accepted by M. Katori 25 February 2000
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Choi-Miura, NH., Takahashi, K., Yoda, M. et al. The novel acute phase protein, IHRP, inhibits actin polymerization and phagocytosis of polymorphonuclear cells. Inflamm. res. 49, 305–310 (2000). https://doi.org/10.1007/PL00000211
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DOI: https://doi.org/10.1007/PL00000211