Abstract
Cyclophosphamide (5 or 10 mg/kg p.o.) and Gold sodium thiomalate (0 or 40 mg/kg i.m.) inhibit after repeated administrations (5 days) all the phases of Nystatin edema, whereas a single administration is ineffective.d-Penicillamine (25 or 100 mg/kg p.o.) inhibits the early phases of Nystatin edema after a single administration whereas repeated administrations are almost ineffective. An early treatment with Cyclophosphamide (2.5 mg/kg p.o.) simply delays the appearance of the secondary lesions of adjuvant arthritis but inhibit the development of the primary lesions. A late treatment with Cyclophosphamide as well as both the types of treatment with Gold sodium thiomalate (10 mg/kg i.m.) are effective against primary and secondary lesions. The only effect ofd-Penicillamine (50 mg/kg p.o.) in adjuvant arthritis is a significant incaease of the intensity of secondary lesions during the late treatment. It is suggested that the anti-inflammatory activity of Cyclophosphamide does not depend exclusively upon its effective on some cell population committed in the inflammatory reactions.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
H.L.F. Currey, J. Harris, R.M. Mason, J. Woodland, T. Beveridge, C.J. Roberts, D.W. Veve, A.St.J. Dixon, J. Davies, R. Owen andSmith,Comparison of Azathioprine, Cyclophosphamide and Gold in Treatment of Rheumatoid Arthritis, Br. Med. J.II, 763–766 (1974).
M.H. Gordon andG.E. Ehrlich,Penicillamine for Treatment of Rheumatoid Arthritis, JAMA229, 1342–1343 (1974).
E. Arrigoni-Martelli, P. Schiatti andD. Selva,The Influence of Anti-Inflammatory and Immunosuppressant Drugs on Nystatin — Induced Edema, Pharmacology5, 215–224 (1971).
E. Arrigoni-Martelli, P. Schiatti andD. Selva,Rifampicin and Alanosine Inhibition of Adjuvant Arthritis in Rats, Pharmac. Res. Commun.3, 239–245 (1971).
J.H. Brown, N.L. Schwartz, H.K. Mackey andH.L. Murray,Prophylactic Effects of Cyclophosphamide in Adjuvant — Induced Arthritis, Arch. int. Pharmacodyn.183, 1–11 (1970).
A.St. Dixon, D.J. Lindsay andE.M. Collins,Immunosuppressive Drugs in Rheumatoid Arthrites, Br. Med. J.I 460 (1971).
J.A.M. Kerckhaert, G.J. van der Bergh andJ.M.N. Willers,Influence of Cyclophosphamide on the Delayed Hypersensitivity of the Mouse, Ann. Immun. (Inst. Pasteur)125 C, 415–426 (1974).
F.P. Alepa, N.J. Zwaifler andA.J. Sliwinski,Immunologic Effect of Cyclophosphamide Treatment in Rheumatoid Arthritis, Arthritis Rheum.13 754–760 (1970).
M.A. Swanson andR.S. Schwartz,Immunosuppressive Therapy. The Relation between Clinical Response and Immunologic Competence, New Engl. J. Med.277, 163–170 (1967).
D.T. Walz, M.J. Di Martino, B. Sutton andA. Misher,SK F 36914 — An Agent for Oral Chrysotherapy, J. Pharmac. exp. Ther.181, 292–297 (1972).
R. Duane Sofia andJ.F. Douglas,The Prophylactic and Therapeutic Effects of Gold Sodium Thiomalate against Adjuvant-Induced Poliarthritis in Rats, Agents and Actions3, 335–343 (1973).
R.H. Freyberg, M. Ziff andJ. Baum, in:Arthritis and Allied Conditions (Ed. J.L. Hollander; Lea and Febiger, Philadelphia, Penn. 1972), p. 455–482.
R.H. Persellin, E.V. Hess andM. Ziff,Effect of a Gold Salt on the Immune Response, Arthritis Rheum.10, 99–106 (1967).
S. Norn,Influence of Anti-Rheumatic Agents on the Release of Histamine from Sensitized Rat Peritoneal Mast Cells: II. Antibody Production, Acta pharmac. tox.26, 470–474 (1968).
R.C. Gerber, M.W. Whitehouse andK.J., Orr,Effect of Gold Preparations on the Development and Passive Transfer of Experimental Allergic Encephalomyelitis in Rats, Proc. Soc. exp. Biol. Med.140, 1379–1384 (1972).
R.S. Ennis, J.L. Granda andA.S. Posner,Effect of Gold Salts and other Drugs on the Release and Activity of Lysosomal Hydrolases, Arthritis Rheum.11, 756–769 (1968).
E. Arrigoni-Martelli andA. Restelli Release of Lysosomal Enzymes in Experimental Inflammations: Effects of Antiinflammatory Drugs, Eur. J. Pharmac.19, 191–198 (1972).
B. Klamer, E.T. Kimura andM. Makstenieks,Effects of Oral Cysteine, Penicillamine, and N-Acetylpenicillamine on Adjuvant Arthritis in Rats, Pharmacology1, 283–288 (1968).
S.P. Liyanage andH.L.F. Currey,Failure of Oral D-Penicillamine to Modify Adjuvant Arthritis or Immunoresponse in the Rat, Ann. Rheum. Dis.31, 521 (1972).
K. Altman andM.S. Tobin,Suppression of the Primary Immune Response Induced by D-L-Pencillamine, Proc. Soc. exp. Biol. Med.118, 553–557 (1965).
K.F. Hübner andN. Gengozian,Depression of the Primary Immune Response by D-L-Penicillamine, Proc. Soc. exp. Biol. Med.118, 561–565 (1965).
M.S. Tobin andK. Altman,Accelerated Immune Response Induced by D-L-Penicillamine, Proc. Soc. exp. Biol. Med.115, 225–228 (1964).
I.A. Jaffe,The Treatment of Rheumatoid Arthritis and Necrotizing Vasculitis with Penicillamine, Arthritis Rheum.13, 436–443 (1970).
Multicenter Trial Group,Controlled Trial of D-Penicillamine in Severe Rheumatoid Arthritis, LancetI, 275–280 (1973).
U. Junge, E. Perings andE. Lubrich,Hemmung von Fibroblastenkulturen durch D-Penicillamine, Klin. Wschr.52, 794–796 (1974).
S. Roath andR. Willis,The EFfects of Penicillamine on Lymphocytes in Culture-Postgrad, Med. J. August Suppl., p. 56–57 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bramm, E.AM.E. Investigations on the influence of Cyclophosphamide, gold sodium thiomalate andd-penicillamine on nystatin oedema and adjuvant arthritis. Agents and Actions 5, 264–267 (1975). https://doi.org/10.1007/BF02026441
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02026441