Skip to main content
SpringerLink
Log in

Pharmacological mediators of various immunological and non-immunological inflammatory reactions produced in the pleural cavity

  • Immunosuppression and Inflammation
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Intrapleural exudates have been produced in rats and guinea-pigs using calcium pyrophosphate, cell mediated immunity, reversed passive Arthus reaction and carrageenan. The intracellular concentration of various pharmacological mediators has been measured at different times during the evolution of these inflammatory responses. These have been correlated with volume of exudate and cellular migration.

The significance of these findings has been discussed and the possible application to the search for new anti-inflammatory agents and their use in diagnostic procedures.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. D.A. Willoughby,Human Arthritis Applied to Animal Models: Towards a Better Therapy, Ann. rheum. Dis., in press (1975).

  2. S. Yamamoto, C.J. Dunn, D.A. Deporter, E.C. Huskisson andD.A. Willoughby,A Model for the Study of Immediate Hypersensitivity in Rats, Agents and Actions, submitted for publication (1975).

  3. S. Yamamoto, C.J. Dunn, F. Capasso, D.A. Deporter andD.A. Willoughby,Quantitative Studies on Cell-Mediated Immunity in the Pleural Cavity of Guinea-Pigs, J. Path,117, 65 (1975).

    Article  PubMed  Google Scholar 

  4. D.A. Willoughby, C.J. Dunn, S. Yamamoto, F. Capasso, D.A. Deporter andJ.P. Giroud,Calcium Pyrophosphate-Induced Pleurisy in Rats: A New Model of Acute Inflammation, Agents and Actions,5, 35 (1975).

    PubMed  Google Scholar 

  5. M. Di Rosa, J.P. Giroud andD.A. Willoughby,Studies of the Mediators of the Acute Inflammatory Response Induced in Rats in Different Sites by Carrageenan and Turpentine, J. Path.104, 15 (1971).

    Article  PubMed  Google Scholar 

  6. G.P. Velo, C.J. Dunn, J.P. Giroud, J. Timsit andD.A. Willoughby,Distribution of Prostaglandins in Inflammatory Exudate, J. Path.111, 149 (1973).

    Article  PubMed  Google Scholar 

  7. F. Capasso, C.J. Dunn, S. Yamamoto, D.A. Willoughby andJ.P. Giroud,Further Studies on Carrageenan-Induced Pleurisy in the Rat, J. Path.116, 117 (1975).

    Article  PubMed  Google Scholar 

  8. W.G. Spector andD.A. Willoughby, in:The Pharmacology of Inflammation (English Universities Press, London 1968).

    Google Scholar 

  9. P. Crunkhorn andA.L. Willis,Cutaneous Reactions to Intradermal Prostaglandins, Br. J. Pharmac.41, 49 (1971).

    Google Scholar 

  10. B. Samuelsson,On the Formation and Properties of an Endoperoxide Intermediate in Prostaglandin Biosynthesis, in:Future Trends in Inflammation (Eds. G.P. Velo, D.A. Willoughby, J.P. Giroud; Piccin Medical Books, Padua and London 1974), p. 5.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Exp. Pathology, St. Bartholomew's Hospital, E.C.1, London, England

    F. Capasso, C. J. Dunn, S. Yamamoto, D. A. Deporter, J. P. Giroud & D. A. Willoughby

  2. Département de Pharmacologie, Faculté de Médecine, Cochin, Paris 14, France

    F. Capasso, C. J. Dunn, S. Yamamoto, D. A. Deporter, J. P. Giroud & D. A. Willoughby

Authors
  1. F. Capasso
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. J. Dunn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. A. Deporter
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. P. Giroud
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D. A. Willoughby
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Capasso, F., Dunn, C.J., Yamamoto, S. et al. Pharmacological mediators of various immunological and non-immunological inflammatory reactions produced in the pleural cavity. Agents and Actions 5, 528–533 (1975). https://doi.org/10.1007/BF01972690

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01972690

Keywords

Search

Navigation