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Platelets, acute inflammation and inflammatory mediators

  • Symposium 6 Studies on Anti-Inflammatory Substances in Animals
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Abstract

The anti-inflammatory activity of aspirin-like drugs could derive, at least in part, by inhibiting synthesis and release of prostaglandins or rabbit aorta-contracting substance from platelets. Indeed, aggregation of platelets and the consequent release of inflammatory mediators has been frequently evoked as a factor in the development of the inflammatory reaction. The participation of platelets in acute inflammation was tested in three types of trauma in rats rendered thrombocytopenic with anti-platelet serum. Oedema in response to carrageenin, anti-platelet serum or passive cutaneous anaphylaxis was no different from the controls in thrombocytopenic rats.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine of Ribeirão Prêto, São Paulo, Brazil

    S. H. Ferreira

  2. The Wellcome Research Laboratories, Langley Court, Beckenham, Kent, England

    F. B. Ubatuba & J. R. Vane

Authors
  1. S. H. Ferreira
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  2. F. B. Ubatuba
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  3. J. R. Vane
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Ferreira, S.H., Ubatuba, F.B. & Vane, J.R. Platelets, acute inflammation and inflammatory mediators. Agents and Actions 6, 313–319 (1976). https://doi.org/10.1007/BF01972248

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