Abstract
Intraocular inflammations (uveitis) were produced in rabbits by intravitreal injection of killed and driedMycobacterium butyricum orE. coli endotoxin, or paracentesis of the anterior chamber. The increase in permeability of the blood-aqueous barrier and the leucocyte migration into the aqueous humor were observed after these stimuli, although the leucocyte did not migrate after paracentesis. Topically applied indomethacin reduced these inflammatory parameters in the latter two models. However, the increased permeability afterM. butyricum injection was not affected by indomethacin, though the leucocyte migration was reduced. On the other hand, prostaglandin-like substances in the aqueous humor were significantly elevated in the latter models, whereas only traces of these substances were detected in the former model. These results indicate that, unlike the increase in the permeability of the blood-aqueous barrier after endotoxin injection and paracentesis, the response afterM. butyricum injection is not mediated by prostaglandins. The role of prostaglandins in the leucocyte migration in these ocular inflammations was also discussed.
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Yamauchi, H., Iso, T. & Iwata, H. The role of prostaglandins in experimental ocular inflammations. Agents and Actions 9, 280–283 (1979). https://doi.org/10.1007/BF01966701
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DOI: https://doi.org/10.1007/BF01966701