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Cyclic AMP of blood platelets: Accumulation in organelles storing 5-hydroxytryptamine and ATP

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Zusammenfassung

Die subzellulären Organellen, welche in Blutplättchen von Ratten und Meerschweinchen 5-Hydroxytryptamin und Adenosin-5′-triphosphat speichern enthalten bis über 100 Mal mehr cyclisches Adenosin-5′-monophosphat (cAMP) als die ganzen Plättchen und die übrigen subzellulären Fraktionen. Durch die Speicherung in subzellulären Organellen kommt es möglicherweise zu einer biologischen Inaktivivierung von cAMP in den Plättchen.

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References

  1. R. W. Butcher, R. E. Scott andE. W. Sutherland, Pharmacologist9, 172 (1967).

    Google Scholar 

  2. S. M. Wolfe andN. R. Shulman, Biochem. Biophys. Res. Commun.35, 265 (1969).

    Article  CAS  Google Scholar 

  3. G. A. Robison, A. Arnold andR. C. Hartmann, Pharmac. Res. Commun.1, 325 (1969).

    Article  CAS  Google Scholar 

  4. P. D. Zieve andB. Greenough, Biochem. Biophys. Res. Commun.35, 1162 (1969).

    Article  Google Scholar 

  5. M. Da Prada andA. Pletscher, Br. J. Pharmac.34, 591 (1968).

    Article  Google Scholar 

  6. U. Goetz, M. Da Prada andA. Pletscher, J. Pharmac. exp. Ther.178, 210 (1971).

    CAS  Google Scholar 

  7. M. Da Prada, A. Pletscher andJ. P. Tranzer, J. Physiol., Lond.217, 679 (1971).

    Article  Google Scholar 

  8. B. L. Brown, J. D. M. Albano, R. P. Ekins andA. M. Sghezzi, Biochem. J.121, 561 (1971).

    Article  CAS  Google Scholar 

  9. A. L. Steiner, D. M. Kipnis, R. Utiger andC. Parker, Proc. natn. Acad. Sci.64, 367 (1969).

    Article  CAS  Google Scholar 

  10. O. H. Lowry, N. J. Rosebrough, A. L. Farr andR. J. Randall, J. biol. Chem.193, 265 (1951).

    Article  CAS  Google Scholar 

  11. W. Y. Cheung, Biochemistry6, 1079 (1967).

    Article  CAS  Google Scholar 

  12. M. Da Prada, A. Pletscher, J. P. Tranzer andH. Knuchel, Nature, Lond.216, 1315 (1967).

    Article  Google Scholar 

  13. W. H. Cook, D. Lipkin andR. Markham, J. Am. chem. Soc.79, 3607 (1957).

    Article  CAS  Google Scholar 

  14. J. Ramachandran, Analyt. Biochem.43, 227 (1971).

    Article  CAS  Google Scholar 

  15. M. Da Prada andA. Pletscher, in preparation.

  16. N. R. Marquis, R. L. Vigdahl andP. A. Tavormina, Biochem. Biophys. Res. Commun.36, 965 (1969).

    Article  CAS  Google Scholar 

  17. G. A. Robison, A. Arnold, B. Cole andR. Hartmann, Ann. N.Y. Acad. Sci.180, 324 (1971).

    Article  CAS  Google Scholar 

  18. G. Ball, G. Brereton, M. Fulwood, D. M. Ireland andP. Yates, Biochem. J.120, 709 (1970).

    Article  CAS  Google Scholar 

  19. R. J. Haslam andA. Taylor, Biochem. J.125, 377 (1971).

    Article  CAS  Google Scholar 

  20. M. J. Droller andS. M. Wolfe Blood38, 791 (1971).

    Google Scholar 

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Authors and Affiliations

  1. Research Department, F. Hoffmann-La Roche & Co. Ltd., CH-4002, Basel, Switzerland

    M. Da Prada, W. P. Burkard & A. Pletscher

Authors
  1. M. Da Prada
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  2. W. P. Burkard
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  3. A. Pletscher
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Da Prada, M., Burkard, W.P. & Pletscher, A. Cyclic AMP of blood platelets: Accumulation in organelles storing 5-hydroxytryptamine and ATP. Experientia 28, 845–846 (1972). https://doi.org/10.1007/BF01923167

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