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In vivo perfusion of human thyroid tissue with 4-14C-dehydroepiandrosterone and 7α-3H-dehydroepiandrosterone sulfate. Metabolism of steroid conjugates. X

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Zusammenfassung

Bei der In vivo-Perfusion menschlichen Schilddrüsen-Strumagewebes mit 4-14C-DHEA und 7α-3H-DHEA-Sulfat zeigte es sich, dass unter physiologischen Bedingungen eine beachtliche Hydrolyse von Steroid-Sulfat eintrat. Demgegenüber liess sich keine Steroid-Sulfokinase oder Steroid-Glucuronosyl-Transferase nachweisen. Der Anteil der Metaboliten erreichte in der Fraktion der freien Steroide ungefähr 30% isolierter Verbindungen, in der Fraktion der Steroid-Sulfate jedoch nur etwa 14%. Androstendiol erwies sich als wichtigster Metabolit, gefolgt von Androstendion und Androstentriol.

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References

  1. G. W. Oertel, P. Knapstein andL. Treiber, Z. physiol. Chem.345, 221 (1966).

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Authors and Affiliations

  1. Abteilung für Experimentelle Endokrinologie, Universitäts-Frauenklinik, Postfach 3960, 65, Mainz, Germany

    G. Schneider, P. Menzel, F. Wendlberger & G. W. Oertel

  2. Chirurg. Abteilung, Caritas-Krankenhaus, 6638, Dillingen/Saar, Germany

    G. Schneider, P. Menzel, F. Wendlberger & G. W. Oertel

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  1. G. Schneider
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  2. P. Menzel
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  3. F. Wendlberger
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  4. G. W. Oertel
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Schneider, G., Menzel, P., Wendlberger, F. et al. In vivo perfusion of human thyroid tissue with 4-14C-dehydroepiandrosterone and 7α-3H-dehydroepiandrosterone sulfate. Metabolism of steroid conjugates. X. Experientia 28, 210–211 (1972). https://doi.org/10.1007/BF01935765

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  • DOI: https://doi.org/10.1007/BF01935765

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